Meloxicam effectively inhibits preterm labor uterine contractions in a chronically catheterized pregnant sheep model: impact on fetal blood flow and fetal-maternal physiologic parameters

American Journal of Obstetrics and Gynecology
Valeria E RacStephen J Lye

Abstract

Preterm birth occurs in 5% to 10% of all pregnancies and is associated with considerable neonatal mortality and morbidity. Effective and safe drugs to prevent preterm labor are not currently available. We have hypothesized that the nonsteroidal anti-inflammatory drug meloxicam, a more selective cyclooxygenase-2 inhibitor will successfully inhibit labor but avoid the complications associated with inhibition of cyclooxygenase-1. Preterm labor was induced in chronically catheterized sheep by RU486 administration. Animals were then randomized to receive maternal infusions of saline (n = 5) or meloxicam (n = 4) for 48 hours or until delivery when the animals were killed and tissues and blood samples collected. Maternal infusion of meloxicam inhibited uterine contractions, increasing contraction duration, and attenuating frequency and amplitude. Saline-treated animals progressed to delivery. Administration of meloxicam was not associated with any change in fetal or maternal blood gas status, osmolality, arterial pressure, heart rate, or fetal blood flows. Meloxicam may represent a potentially safe and effective tocolytic agent.

References

Nov 1, 1992·American Journal of Obstetrics and Gynecology·S J LyeR F Casper
Mar 1, 1991·American Journal of Perinatology·B KirshonR Willis
Nov 1, 1994·American Journal of Obstetrics and Gynecology·M P WalkerR A Brace
Apr 1, 1993·American Journal of Obstetrics and Gynecology·K HigbyC J Pauerstein
Apr 1, 1994·American Journal of Obstetrics and Gynecology·A Gerson
Nov 25, 1993·The New England Journal of Medicine·M E NortonR I Clyman
Jan 29, 1993·Biochemical and Biophysical Research Communications·L H WangK K Wu
Nov 13, 1998·The New England Journal of Medicine·K S JosephR Platt
Aug 3, 1999·British Journal of Obstetrics and Gynaecology·K R PanterD Farine
Aug 31, 2000·Annual Review of Biochemistry·W L SmithR M Garavito
Jul 2, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·John R G ChallisJohn P Newnham
Sep 19, 2002·American Journal of Obstetrics and Gynecology·Catherine S StikaYoel Sadovsky

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Citations

Apr 12, 2008·Reproduction, Fertility, and Development·D W RurakN C Gruber
Jan 1, 1968·Acta Anaesthesiologica Scandinavica. Supplementum·P F Scholander, R W Elsner
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·A C Hirsch, H Philipp
Jan 1, 2012·Pharmaceuticals·Francine G SmithWei Qi
Jan 30, 2019·Australian Veterinary Journal·I G ColditzA H Small
Feb 1, 2020·Animal Frontiers : the Review Magazine of Animal Agriculture·Tamara J VarcoeJanna L Morrison

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