Meloxicam modulates oxidative stress status, inhibits prostaglandin E2, and abrogates apoptosis in carbon tetrachloride-induced rat hepatic injury

International Journal of Toxicology
Mohamed EdfawyHebat Allah A Amin

Abstract

The current study aimed at investigating the potential hepatoprotective property and mechanism of meloxicam (MEL) against carbon tetrachloride (CCl(4))-induced hepatocellular damage in rats. Subcutaneous administration of CCl(4) (2 mL/kg, twice/week for 8 weeks) induced hepatocellular damage substantiated by hematoxylin and eosin staining and significant elevation in serum aspartate transaminase, alanine transaminase, and total bilirubin. In addition, CCL(4) treatment led to elevation in liver contents of lipid peroxidation marker (malondialdehyde), prostaglandin E2, active caspase 3, and Terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells and reduction in the activities of superoxide dismutase, catalase, glutathione-S-transferase, and reduced glutathione in the liver tissue. Prior oral treatment with MEL (5 mg/kg, twice/week) retained the normal liver histology and significantly restored all of these parameters close to normal values. These results demonstrated the hepatoprotective utility of MEL against the CCl(4)-induced liver injury which might ascribe to its antioxidant, free radical scavenging, antiapoptotic and anti-inflammatory effects.

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Citations

Jul 24, 2014·Cancer Chemotherapy and Pharmacology·Memy H HassanMohamed M Ghobara
May 7, 2014·Journal of Biochemical and Molecular Toxicology·Memy H HassanGamil M Abd-Allah
Jun 2, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Memy H Hassan, Mohamed M Ghobara
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Sep 12, 2019·Frontiers in Veterinary Science·Sina RehbeinBarbara Kohn
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Jun 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ziye ZhuYanqi Dang

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Methods Mentioned

BETA
MDA

Software Mentioned

SPSS
Sigma Stat

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis