PMID: 11339520May 8, 2001Paper

Meloxicam oral suspension: a treatment alternative to solid meloxicam formulations

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
G HanftR Sigmund

Abstract

This paper reviews recent studies that have aimed to establish the relative bioavailability of a new oral formulation of meloxicam, and to evaluate its safety and efficacy in a clinical setting. For the bioavailability study, 16 healthy volunteers were randomised to receive either an oral or a solid formulation of meloxicam 15 mg. The performance of the oral suspension was tested in 286 patients with osteoarthritis who were randomised to receive either formulation at 7.5 mg daily. It was found that the new oral suspension was bioequivalent to the capsules formulation, and was more rapidly absorbed after a single dose. No clinical differences were observed in both efficacy and tolerability parameters with either type of formulation in patients with osteoarthritis. The oral suspension was well accepted by the patients. Hence, the oral suspension provides a useful alternative to solid formulations in the treatment of inflammatory joint diseases and painful musculoskeletal disorders.

Citations

Apr 2, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Levente KürtiPiroska Szabó-Révész
Jul 21, 2009·International Journal of Pharmaceutics·R AmbrusP Szabó-Révész
Aug 3, 2004·Journal of Clinical Pharmacology·Rubén Burgos-VargasDietrich Tuerck
Oct 24, 2006·International Journal of Pharmaceutics·Maria Adolfina Ruiz MartinezVisitación Gallardo Lara
Aug 22, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hyo-Kyung Han, Hoo-Kyun Choi
Oct 18, 2016·Drug Delivery·Motaz FaridTahany El-Bayomi
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas Thum, Jürgen Borlak
Sep 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gailute DraksieneJurga Bernatoniene
May 1, 2021·Animals : an Open Access Journal From MDPI·Alison SmallIan Colditz

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