Melphalan exposure induces an interleukin-6 deficit in bone marrow stromal cells and osteoblasts.

Cytokine
Stephanie L RellickLaura F Gibson

Abstract

Bone marrow stromal cells (BMSC) and osteoblasts are critical components of the microenvironment that support hematopoietic recovery following bone marrow transplantation. Aggressive chemotherapy not only affects tumor cells, but also influences additional structural and functional components of the microenvironment. Successful reconstitution of hematopoiesis following stem cell or bone marrow transplantation after aggressive chemotherapy is dependent upon components of the microenvironment maintaining their supportive function. This includes secretion of soluble factors and expression of cellular adhesion molecules that impact on development of hematopoietic cells. In the current study, we investigated the effects of chemotherapy treatment on BMSC and human osteoblast (HOB) expression of interleukin-6 (IL-6) as one regulatory factor. IL-6 is a pleiotropic cytokine which has diverse effects on hematopoietic cell development. In the current study we demonstrate that exposure of BMSC or HOB to melphalan leads to decreases in IL-6 protein expression. Decreased IL-6 protein is the most pronounced following melphalan exposure compared to several other chemotherapeutic agents tested. We also observed that melphalan decreased IL-6 mRN...Continue Reading

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Citations

Feb 3, 2016·Cell Biochemistry and Function·Zuo-Lin LinJung-Hsin Hsu
Jul 1, 2017·Expert Opinion on Pharmacotherapy·Fabrizio EsmaChiara Pautasso
Oct 20, 2017·Blood·James N Cooper, Neal S Young
Nov 24, 2020·Cancer Investigation·Hassan RafieemehrNajmaldin Saki

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