Melphalan, prednisone, and lenalidomide versus melphalan, prednisone, and thalidomide in untreated multiple myeloma.

Blood
Sonja ZweegmanAnders Waage

Abstract

The combination of melphalan, prednisone, and thalidomide (MPT) is considered standard therapy for newly diagnosed patients with multiple myeloma who are ineligible for stem cell transplantation. Long-term treatment with thalidomide is hampered by neurotoxicity. Melphalan, prednisone, and lenalidomide, followed by lenalidomide maintenance therapy, showed promising results without severe neuropathy emerging. We randomly assigned 668 patients between nine 4-week cycles of MPT followed by thalidomide maintenance until disease progression or unacceptable toxicity (MPT-T) and the same MP regimen with thalidomide being replaced by lenalidomide (MPR-R). This multicenter, open-label, randomized phase 3 trial was undertaken by Dutch-Belgium Cooperative Trial Group for Hematology Oncology and the Nordic Myeloma Study Group (the HOVON87/NMSG18 trial). The primary end point was progression-free survival (PFS). A total of 318 patients were randomly assigned to receive MPT-T, and 319 received MPR-R. After a median follow-up of 36 months, PFS with MPT-T was 20 months (95% confidence interval [CI], 18-23 months) vs 23 months (95% CI, 19-27 months) with MPR-R (hazard ratio, 0.87; 95% CI, 0.72-1.04; P = .12). Response rates were similar, with at...Continue Reading

References

Aug 31, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda MileshkinH Miles Prince
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio PalumboUNKNOWN GIMEMA--Italian Multiple Myeloma Network
Aug 30, 2008·The New England Journal of Medicine·Jesús F San MiguelUNKNOWN VISTA Trial Investigators
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cyrille HulinPhilippe Moreau
May 8, 2010·Blood·Anders WaageUNKNOWN Nordic Myeloma Study Group
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre WijermansUNKNOWN Dutch-Belgium Cooperative Group HOVON
Oct 25, 2011·Blood·Gareth J MorganUNKNOWN National Cancer Research Institute Haematological Oncology Clinical Studies Group
Mar 1, 2012·Haematologica·Fiona M RossUNKNOWN European Myeloma Network
May 11, 2012·The New England Journal of Medicine·Antonio PalumboUNKNOWN MM-015 Investigators
Dec 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jesús F San MiguelPaul G Richardson
Sep 3, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gareth J MorganJ Anthony Child
Feb 15, 2014·The Lancet Oncology·Guy Pratt
Sep 4, 2014·The New England Journal of Medicine·Lotfi BenboubkerUNKNOWN FIRST Trial Team

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Citations

May 26, 2016·Expert Opinion on Biological Therapy·Myrna R Nahas, David Avigan
Jun 9, 2016·Expert Review of Hematology·Pellegrino Musto, Vittorio Montefusco
Oct 22, 2016·Blood Cancer Journal·B LipeJ Mikhael
Feb 17, 2017·Therapeutic Advances in Hematology·Shahzad RazaSuzanne Lentzsch
Jul 1, 2017·Expert Opinion on Pharmacotherapy·Fabrizio EsmaChiara Pautasso
Aug 30, 2017·Leukemia & Lymphoma·Evan DiamondHeather Landau
Jun 6, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Jéssica de Castro AlvesTatiana Chama Borges Luz
Jun 23, 2018·Expert Review of Anticancer Therapy·Paul G RichardsonPeter O'Gorman
Oct 26, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masanobu TsubakiShozo Nishida
Apr 2, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph MikhaelTom Martin
Feb 21, 2019·Expert Opinion on Pharmacotherapy·Jessica L DempseyHillard M Lazarus
Dec 10, 2017·Hematology·María-Victoria Mateos, Jesús F San Miguel
May 18, 2019·American Society of Clinical Oncology Educational Book·Roberto MinaAshley E Rosko
Mar 8, 2020·European Journal of Haematology·Manuel David Gil-SierraEmilio Jesus Alegre-Del Rey
Dec 21, 2017·Expert Review of Hematology·Hussein G Elsayed, Amal S Alabdulwahab
Jan 21, 2019·Current Hematologic Malignancy Reports·Sarah A HolsteinPhilip L McCarthy
Oct 3, 2019·Ciência & saúde coletiva·Francisco José Roma Paumgartten
Sep 9, 2016·The Korean Journal of Internal Medicine·Ho Sup Lee, Chang-Ki Min
Jul 4, 2020·Signal Transduction and Targeted Therapy·Zhe ZhangCanhua Huang
Apr 22, 2020·American Society of Clinical Oncology Educational Book·Philippe MoreauAshley E Rosko
May 23, 2020·Clinical Interventions in Aging·Kelly L Schoenbeck, Tanya M Wildes
Jul 7, 2020·Leukemia & Lymphoma·Shebli AtrashSaad Z Usmani
Jul 18, 2018·Therapeutic Advances in Hematology·Sarah A HolsteinPhilip L McCarthy
Dec 29, 2020·Journal of the Peripheral Nervous System : JPNS·Martin BallegaardPeter Gimsing
Dec 27, 2019·Seminars in Cancer Biology·Aurora Gonzalez-Fierro, Alfonso Dueñas-González
Sep 22, 2020·Panminerva Medica·Daniele DerudasClaudio Cerchione
Mar 23, 2021·British Journal of Haematology·Jonathan SiveUNKNOWN British Society of Haematology
Oct 14, 2020·Journal of Geriatric Oncology·Henry ChanSharon Jackson
Apr 20, 2021·Drugs·Radowan A Elnair, Sarah A Holstein
Jun 3, 2021·Cancers·Fredrik Schjesvold, Albert Oriol

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