Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement: a comparative study

Journal of Pharmaceutical Sciences
Attila BaloghGyörgy Marosi

Abstract

Melt blowing (MB) was investigated to prepare a fast dissolving fibrous drug-loaded solid dispersion and compared with solvent-based electrospinning (SES) and melt electrospinning (MES). As a conventional solvent-free technique coupled with melt extrusion and using a high-speed gas stream, MB can provide high-quality micro- and nanofibers at industrial throughput levels. Carvedilol, a weak-base model drug with poor water solubility, was processed using a common composition optimized for the fiber spinning and blowing methods based on a hydrophilic vinylpyrrolidone-vinyl acetate copolymer (PVPVA64) and PEG 3000 plasticizer. Scanning electron microscopy combined with fiber diameter analysis showed diameter distributions characteristic to each prepared fibrous fabrics (the mean value increased toward SES<MB<MES). Differential scanning calorimetry and X-ray diffraction studies revealed that the incorporated drug was in amorphous form regardless the preparation method. The HPLC studies demonstrated that all of the materials produced by the different techniques passed the regulatory purity requirements. The fibers exhibited ultrafast drug release tested under neutral pH conditions; the melt-blown sample dissolved within 2 min owing t...Continue Reading

References

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Citations

Sep 28, 2015·International Journal of Pharmaceutics·U Eranka IllangakoonGareth R Williams
Sep 1, 2015·International Journal of Pharmaceutics·Attila BaloghZsombor Kristóf Nagy
Jun 6, 2015·International Journal of Pharmaceutics·Xia WangGareth R Williams
Jan 21, 2017·Nanoscale Research Letters·Guang-Zhi YangDeng-Guang Yu
Mar 10, 2017·Drug Development and Industrial Pharmacy·Tamás VighZsombor K Nagy
May 6, 2021·Macromolecular Bioscience·Matin RostamitabarSamaneh Ghazanfari
Jun 8, 2021·International Journal of Pharmaceutics·Sidra NasirMuhammad Sohail Arshad
Jun 13, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Edina SzabóZsombor K Nagy

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