Melt extrusion with poorly soluble drugs - An integrated review

International Journal of Pharmaceutics
Michael A RepkaAjinkya M Bhagurkar

Abstract

Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This review is focused on the recent reports on the solubility enhancement via HME and provides an update for the manufacturing/scaling up aspects of melt extrusion. In addition, drug characterization methods and dissolution studies are discussed. The application of process analytical technology (PAT) tools and use of HME as a continuous manufacturing process may shorten the drug development process; as a result, the latter is becoming the most widely utilized technique in the pharmaceutical industry. The advantages, disadvantages, and practical applications of various PAT tools such as near and mid-infrared, ultraviolet/visible, fluorescence, and Raman spectroscopies are summarized, and the characteristics of other techniques are briefly discussed. Overall, this review also provides an outline for the currently marketed products and analyzes the strengths, weaknesses, opportunities and threats of HME application in the phar...Continue Reading

Citations

Aug 3, 2018·The Journal of Pharmacy and Pharmacology·Felix DitzingerMartin Kuentz
Apr 23, 2019·Expert Opinion on Drug Delivery·Venkata Raman KallakuntaMichael A Repka
Oct 23, 2019·Pharmaceutical Development and Technology·Mohammed Rohi SanoufiNizar Al-Zoubi
Jul 6, 2019·Journal of Food Science and Technology·Kenji IshimotoShinsaku Nakagawa
Jul 1, 2020·Pharmaceutics·Martin SpoerkAmrit Paudel
Nov 30, 2018·The Journal of Pharmacy and Pharmacology·Ajinkya M BhagurkarMichael A Repka
Nov 9, 2020·AAPS PharmSciTech·Athira R NairSwapnil J Dengale
Oct 18, 2020·International Journal of Pharmaceutics·Stephan SacherJohannes G Khinast
Dec 22, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Esther S BochmannBernd Liepold
Dec 7, 2019·International Journal of Pharmaceutics·Shivprasad DeshmukhAdrian Kelly
Dec 1, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Arun ButreddyMichael A Repka
Feb 12, 2021·Advanced Drug Delivery Reviews·Suresh BandariMichael A Repka
Dec 17, 2020·Polymers·Ioannis KoutsamanisEva Roblegg
Jan 27, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rydvikha GovenderStaffan Folestad
Feb 9, 2020·International Journal of Pharmaceutics·Konstantinos KatopodisPanagiotis Barmpalexis
Mar 16, 2021·Journal of Drug Delivery Science and Technology·Sagar NaralaMichael A Repka
Mar 23, 2021·International Journal of Pharmaceutics·Nagireddy DumpaMichael A Repka
Apr 30, 2021·Frontiers in Pharmacology·Hilda AmekyehNashiru Billa

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