Memantine ER Maintains Patient Response in Moderate to Severe Alzheimer's Disease: Post Hoc Analyses From a Randomized, Controlled, Clinical Trial of Patients Treated With Cholinesterase Inhibitors

Alzheimer Disease and Associated Disorders
George T GrossbergJohn Edwards

Abstract

Memantine extended release (ER) significantly outperformed placebo on co-primary endpoints of Clinician's Interview-based Impression of Change Plus Caregiver Input (CIBIC-Plus) and baseline to endpoint changes on the Severe Impairment Battery (SIB) in a 24-week, randomized trial (NCT00322153) in patients with moderate to severe Alzheimer's disease taking a cholinesterase inhibitor (ChEI). A post hoc analysis compared patients receiving memantine ER/ChEI to placebo/ChEI for time to onset of response and if the response was maintained (achieving improvement at weeks 8, 12, or 18 and maintaining through endpoint/week 24) on the SIB, the Neuropsychiatric Inventory (NPI), CIBIC-Plus, and Activities of Daily Living (ADL) using Fisher exact test. A second post hoc analysis compared percentages of patients for all possible combinations of 2 to 4 assessments with either no decline or clinically notable response using Wald χ. Significantly greater percentages of memantine ER/ChEI patients achieved an early response that was maintained on SIB, NPI, and CIBIC-Plus (P<0.05) versus placebo/ChEI. Significantly greater percentages of memantine ER/ChEI-treated patients achieved and maintained a clinically notable response on ADL/NPI, SIB/ADL/NP...Continue Reading

References

Apr 4, 2003·The New England Journal of Medicine·Barry ReisbergUNKNOWN Memantine Study Group
Jan 22, 2004·JAMA : the Journal of the American Medical Association·Pierre N TariotUNKNOWN Memantine Study Group
Sep 24, 2004·Drugs & Aging·Carmel M Hughes
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Dec 15, 2005·Neuroepidemiology·R S WilsonD A Evans
Mar 15, 2006·International Journal of Geriatric Psychiatry·Robert S WilsonDenis A Evans
Jun 2, 2007·The American Journal of Psychiatry·Robert S WilsonDenis A Evans
Sep 26, 2007·Current Medical Research and Opinion·Gary Small, Bruno Dubois
Jan 5, 2012·Alzheimer Disease and Associated Disorders·Ron L H HandelsJohan L Severens
Oct 30, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Susan D RountreeRachelle S Doody

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Clinical Trials Mentioned

NCT00322153

Software Mentioned

CIBIC
Plus

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