Memantine has no effect on KATP channels in pancreatic β cells

BMC Research Notes
Ryota ImaiKenju Shimomura

Abstract

Memantine, a drug for Alzheimer's disease, is considered to suppress excessive stimulation of N-methyl-D-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal KATP channel also can become a target of memantine. The KATP channel is a key regulator of insulin secretion in pancreatic β cells. Therefore, if memantine could inhibit the KATP channel in pancreatic β cells, it would be an effective drug for both Alzheimer's disease and diabetes. However, there is no report on the effect of memantine on the KATP channel in pancreatic β cells. Therefore, we investigated whether memantine affect the blood glucose level, insulin secretion and KATP channel activity in pancreatic β cells. An intraperitoneal glucose tolerance test was performed with or without memantine (1 mg/kg) injection in intact mice. Insulin secretion from isolated islets was measured under low (2 mM) and high (20 mM) glucose concentrations with or without memantine (1 μM). The effect of memantine (1 μM) on KATP channel currents in isolated pancreatic β cells was recorded using the whole-cell patch-clamp technique. Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or KATP chann...Continue Reading

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Citations

Jul 16, 2020·The Journal of Pharmacology and Experimental Therapeutics·Anne Gresch, Martina Düfer
Mar 25, 2021·Clinical Pharmacology in Drug Development·Jin-Woo ParkJi-Young Park

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Methods Mentioned

BETA
ELISA

Software Mentioned

pCLAMP
Clampfit

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