Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cells.

Neuroscience Letters
Balmiki RayD K Lahiri

Abstract

Memantine, an uncompetitive NMDA receptor antagonist, is a FDA-approved drug used for the treatment of moderate-to-severe Alzheimer's disease (AD). Several studies have documented protective roles of memantine against amyloid beta (A beta) peptide-mediated damage to neurons in both in vitro and in vivo models. Memantine is also effective in reducing amyloid burden in the brain of APP transgenic mice. However, the exact mechanism by which memantine provides protection against A beta-mediated neurodegenerative cascade, including APP metabolism, remains to be elucidated. Herein, we investigated the effect of memantine on levels of the secreted form of A beta precursor protein (APP), secreted A beta and cell viability markers under short/acute conditions. We treated neuronal SK-N-SH cells with 10 microM memantine and measured levels of secreted total APP (sAPP), APP alpha isoform and A beta((1-40)) in a time dependent manner for up to 24h. Memantine significantly decreased the levels of the secreted form of sAPP, sAPP alpha and A beta((1-40)) compared to vehicle treated cells. This change started as early as 8h and continued for up to 24h of drug treatment. Unlike sAPP, a slight non-significant increase in total intracellular APP l...Continue Reading

References

Apr 15, 1994·Journal of Neuroscience Research·D K LahiriM R Farlow
Nov 14, 1998·Brain Research. Molecular Brain Research·D K LahiriK Sambamurti
Jun 12, 2001·Current Opinion in Neurobiology·S Cull-CandyM Farrant
May 25, 2002·Neuromolecular Medicine·Kumar SambamurtiDebomoy K Lahiri
Dec 21, 2002·The European Journal of Neuroscience·Marina PizziPierFranco Spano
Apr 3, 2003·Neuron·Flavio KamenetzRoberto Malinow
Jul 25, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Elaine R PeskindScott McDonald
Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hongxin DongJohn G Csernansky
Jul 25, 2008·The Journal of Biological Chemistry·Gopal Thinakaran, Edward H Koo
Aug 12, 2008·Channels·Anna KlodaDavid J Adams
May 22, 2009·Journal of Neurochemistry·Cristina Guardia-LaguartaAlberto Lleó
Jul 25, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Henri J HuttunenDora M Kovacs

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Citations

Aug 27, 2013·Neuropharmacology·Sandra I MotaA Cristina Rego
Aug 17, 2012·Journal of Psychiatry & Neuroscience : JPN·Timothy J RevettSatyabrata Kar
Mar 16, 2019·Scientific Reports·Simona SestitoSimona Rapposelli
Jan 21, 2011·Nature Reviews. Neuroscience·Amantha Thathiah, Bart De Strooper
Jun 1, 2012·British Journal of Pharmacology·Wojciech Danysz, Chris G Parsons
Sep 22, 2012·International Journal of Geriatric Psychiatry·Armando PiccinniLiliana Dell'Osso
Sep 1, 2016·Annals of Laboratory Medicine·Min Young KimDoo Yeoun Cho
Mar 10, 2011·Expert Opinion on Pharmacotherapy·Nathan HerrmannKrista Lanctôt
Nov 21, 2017·Small·Elena Sánchez-LópezMaria Francesca Cordeiro
Feb 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jung-A A WooStephen B Liggett
Feb 19, 2020·Translational Psychiatry·Balmiki RayDebomoy K Lahiri
Jan 2, 2021·International Journal of Molecular Sciences·Amanda B ChaiIngrid C Gelissen
Jul 31, 2021·Frontiers in Aging Neuroscience·Anna GasiorowskaGrazyna Niewiadomska

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