Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats.

Metabolic Brain Disease
Gislaine Z RéusJoão Quevedo

Abstract

Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist and several studies have pointed to the NMDA receptor antagonists as a potential therapeutic target for the treatment of depression. The present study was aimed to evaluate the behavioral and physiological effects of administration of memantine in rats exposed to the chronic mild stress (CMS) model. To this aim, after 40 days of exposure to CMS procedure, rats were treated with memantine (20 mg/kg) for 7 days. In this study, sweet food consumption, adrenal gland weight, corticosterone levels, and brain-derived-neurotrophic factor (BDNF) protein levels in the prefrontal cortex, hippocampus and amygdala were assessed. Our results demonstrated that chronic stressful situations induced anhedonia, hypertrophy of adrenal gland weight, and an increase of corticosterone levels in rats, but did not alter BDNF protein levels in the rat brain. Memantine treatment reversed anhedonia and the increase of adrenal gland weight, normalized corticosterone levels and increased BDNF protein levels in the prefrontal cortex in stressed rats. Finally, these findings further support the hypothesis that NMDA receptor antagonists such as memantine could be helpful in the pharmacological trea...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1982·Archiv für Psychiatrie und Nervenkrankheiten·J S KimH H Kornhuber
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J Katz
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
Jun 1, 1993·Pharmacology & Toxicology·E MorylG Quack
Apr 2, 1999·Trends in Pharmacological Sciences·C A Altar
Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Jun 29, 2000·QJM : Monthly Journal of the Association of Physicians·T M O'ConnorF Shanahan
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
May 1, 2001·Nature Medicine·H K ManjiD S Charney
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
May 2, 2003·Annals of the New York Academy of Sciences·Wayne C Drevets
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kenji HashimotoMasaomi Iyo
Oct 30, 2004·Drug News & Perspectives·Kiyofumi Yamada, Toshitaka Nabeshima
May 17, 2005·Brain Research. Molecular Brain Research·Félicien KaregeRomano La Harpe
Dec 22, 2005·Current Opinion in Pharmacology·Jon W Johnson, Shawn E Kotermanski
Feb 8, 2006·Life Sciences·Benício N FreyFlávio Kapczinski
May 19, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hideaki MitaniRyuzou Kawahara
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
Jun 5, 2007·Clinical Neuropharmacology·James M Ferguson, Richard N Shingleton
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman
Sep 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lêda S B GarciaJoão Quevedo
Dec 14, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Gislaine Z RéusJoão Quevedo
Jun 20, 2008·Journal of Psychopharmacology·S H WangB A Chen
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Jan 28, 2009·Neurochemistry International·Giancarlo LuccaJoão Quevedo
Mar 24, 2009·Current Neuropharmacology·G RammesC G Parsons
May 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lêda S B GarciaJoão Quevedo
Jun 2, 2009·Brain Research Reviews·Kenji Hashimoto
Oct 20, 2009·Trends in Pharmacological Sciences·Phil SkolnickRamon Trullas

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Citations

Feb 2, 2013·CNS Spectrums·Mario Catena-Dell'OssoDonatella Marazziti
Mar 13, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph P Steiner, Avindra Nath
May 14, 2014·Journal of Psychiatric Research·Gislaine Z RéusJoão Quevedo
Mar 25, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Murat TopdagMete Iseri
Oct 16, 2012·Acta Diabetologica·Luciane B CerettaJoão Quevedo
Feb 29, 2016·Pharmacological Reports : PR·Karolina PytkaBarbara Filipek
Dec 15, 2012·Behavioural Brain Research·Gislaine Z RéusJoão Quevedo
Apr 8, 2014·Fundamental & Clinical Pharmacology·Véronique MorelLaurence Daulhac
Jul 3, 2013·European Journal of Pharmacology·Véronique MorelGisèle Pickering
Feb 15, 2013·Toxicology and Industrial Health·Mansour A Al-HazmiAyat Os Montasser
Feb 19, 2015·Journal of Psychopharmacology·Níall LallyCarlos A Zarate
Dec 7, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Samira S ValvassoriJoão Quevedo
Nov 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brendan D HareWilliam A Falls
Jul 23, 2019·Expert Review of Neurotherapeutics·Bartłomiej PochwatBernadeta Szewczyk
Jul 18, 2015·Metabolic Brain Disease·Li-Tao YiQing Liu
Jul 12, 2017·Molecular Neurobiology·Marcos Roberto de OliveiraJoão Quevedo
Nov 28, 2018·Neuroscience and Biobehavioral Reviews·Elizabeth T Barfield, Shannon L Gourley
Jul 1, 2020·Life Sciences·Meysam AmidfarYong-Ku Kim
Sep 18, 2021·Journal of Complementary & Integrative Medicine·Mohammad SahraeiGholam Hossein Meftahi

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