Members of the Candida parapsilosis Complex and Candida albicans are Differentially Recognized by Human Peripheral Blood Mononuclear Cells

Frontiers in Microbiology
Eine Estrada-MataHéctor M Mora-Montes

Abstract

The systemic infections caused by members of the Candida parapsilosis complex are currently associated to high morbility and mortality rates, and are considered as relevant as those caused by Candida albicans. Since the fungal cell wall is the first point of contact with the host cells, here we performed a comparison of this organelle in members of the C. parapsilosis complex, and its relevance during interaction with human peripheral blood mononuclear cells (PBMCs). We found that the wall of the C. parapsilosis complex members is similar in composition, but differs to that from C. albicans, with less mannan content and more β-glucan and porosity levels. Furthermore, lectin-based analysis showed increased chitin and β1,3-glucan exposure at the surface of C. parapsilosis sensu lato when compared to C. albicans. Yeast cells of members of the C. parapsilosis complex stimulated more cytokine production by human PBMCs than C. albicans cells; and this significantly changed upon removal of O-linked mannans, indicating this wall component plays a significant role in cytokine stimulation by C. parapsilosis sensu lato. When inner wall components were exposed on the wall surface, C. parapsilosis sensu stricto and C. metapsilosis, but not ...Continue Reading

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Citations

Jun 20, 2018·Frontiers in Immunology·Surabhi GoyalHortense Slevogt
Dec 19, 2019·Frontiers in Microbiology·Marco J Hernández-ChávezHéctor M Mora-Montes
Jun 13, 2020·Frontiers in Cellular and Infection Microbiology·Louise A Walker, Carol A Munro
Dec 21, 2016·Frontiers in Microbiology·María J Navarro-AriasHéctor M Mora-Montes
Jan 27, 2018·Journal of Fungi·Marco J Hernández-ChávezHéctor M Mora-Montes
Sep 2, 2020·Journal of Fungi·Laura C García-CarneroHéctor M Mora-Montes
Aug 27, 2019·Frontiers in Microbiology·Aiysha ThompsonSelinda J Orr
Mar 1, 2019·Clinical Microbiology Reviews·Renáta TóthAttila Gácser
Jun 23, 2021·International Journal of Biological Macromolecules·Maria Valentina DinuAna Clara Aprotosoaie

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Methods Mentioned

BETA
protein assay
fluorescence microscopy
glycosylation

Software Mentioned

GraphPad Prism
Adobe Photoshop

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