Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer

Scientific Reports
Magdalena GrillRudolf Schicho

Abstract

Preclinical studies have demonstrated that the endocannabinoid system (ECS) plays an important role in the protection against intestinal inflammation and colorectal cancer (CRC); however, human data are scarce. We determined members of the ECS and related components of the 'endocannabinoidome' in patients with inflammatory bowel disease (IBD) and CRC, and compared them to control subjects. Anandamide (AEA) and oleoylethanolamide (OEA) were increased in plasma of ulcerative colitis (UC) and Crohn's disease (CD) patients while 2-arachidonoylglycerol (2-AG) was elevated in patients with CD, but not UC. 2-AG, but not AEA, PEA and OEA, was elevated in CRC patients. Lysophosphatidylinositol (LPI) 18:0 showed higher levels in patients with IBD than in control subjects whereas LPI 20:4 was elevated in both CRC and IBD. Gene expression in intestinal mucosal biopsies revealed different profiles in CD and UC. CD, but not UC patients, showed increased gene expression for the 2-AG synthesizing enzyme diacylglycerol lipase alpha. Transcripts of CNR1 and GPR119 were predominantly decreased in CD. Our data show altered plasma levels of endocannabinoids and endocannabinoid-like lipids in IBD and CRC and distinct transcript profiles in UC and CD...Continue Reading

References

Jul 31, 1999·Journal of Neurochemistry·C HsiehK Mackie
Sep 2, 2003·Gastroenterology·Alessia LigrestiVincenzo Di Marzo
Jan 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giuseppe D'ArgenioVincenzo Di Marzo
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Edward S KimballPamela J Hornby
Sep 13, 2006·Gut·V Di Marzo, A A Izzo
Jan 17, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M CôtéV Di Marzo
Sep 19, 2007·British Journal of Pharmacology·E RybergP J Greasley
Feb 19, 2008·Journal of Lipid Research·Vitali MatyashDominik Schwudke
Apr 15, 2008·Journal of Neuroscience Methods·Natasha L GrimseyE Scott Graham
Jun 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jürg GertschAndreas Zimmer
Aug 5, 2008·Cancer Research·Dingzhi WangRaymond N DuBois
Oct 11, 2008·Journal of Biochemistry·Saori OkaTakayuki Sugiura
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Francesca Borrelli, Angelo A Izzo
May 2, 2009·Inflammatory Bowel Diseases·Martin A StorrKeith A Sharkey
May 30, 2009·International Journal of Cancer. Journal International Du Cancer·Antonietta SantoroMaurizio Bifulco
Aug 20, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Francesca BorrelliAngelo A Izzo
Jan 26, 2010·Biochimie·Stefania PetrosinoVincenzo Di Marzo
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
Mar 2, 2011·The American Journal of Pathology·Allisson Freire BentoJoão B Calixto
May 3, 2011·Gastroenterology·Jacques CosnesAntoine Cortot
May 10, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mireille AlhouayekGiulio G Muccioli
Jun 7, 2011·Biochimica Et Biophysica Acta·Natasha L GrimseyMichelle Glass
Jul 29, 2011·European Journal of Gastroenterology & Hepatology·Simon LalHillary Steinhart
Dec 20, 2011·Diabetes·José María Moreno-NavarreteRuben Nogueiras
Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabriella AvielloAngelo A Izzo
May 9, 2012·Trends in Pharmacological Sciences·Harald S HansenThue W Schwartz
Aug 25, 2012·Trends in Molecular Medicine·Mireille Alhouayek, Giulio G Muccioli
Oct 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Samreen K SyedAlexander M Efanov
May 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Timna NaftaliFred Meir Konikoff
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mireille AlhouayekGiulio G Muccioli
Nov 5, 2013·Inflammatory Bowel Diseases·Jessica Ravikoff AllegrettiJonathan Levine

❮ Previous
Next ❯

Citations

Jan 4, 2020·Clinical and Translational Gastroenterology·Melanie KienzlRudolf Schicho
Apr 23, 2020·International Journal of Molecular Sciences·Adam StasiulewiczAnd Joanna I Sulkowska
Aug 1, 2020·Expert Opinion on Pharmacotherapy·Adrian Szczepaniak, Jakub Fichna
Oct 1, 2020·Phytotherapy Research : PTR·Ester PaganoFrancesca Borrelli
Jun 27, 2020·International Journal of Molecular Sciences·Osnat Almogi-Hazan, Reuven Or
Apr 8, 2020·World Journal of Gastroenterology : WJG·Zhen ZengHu Zhang
Sep 15, 2020·Frontiers in Pharmacology·Shinsuke OtagiriNaoya Sakamoto
Dec 10, 2020·Phytotherapy Research : PTR·Marcella PesceGiuseppe Esposito
Jan 27, 2021·International Journal of Molecular Sciences·Dong-Soon Im
Mar 7, 2021·Communications Biology·Andrea NuzzoJames R Brown
Apr 27, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrícia AlvesGeorgina Correia-da-Silva
Apr 13, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katja SchmitzIrmgard Tegeder
May 13, 2021·Journal of Cell Communication and Signaling·Roger Gregory Biringer
Jun 1, 2021·Frontiers in Molecular Biosciences·María Isabel Delgado-DolsetAlma Villaseñor
Jun 15, 2021·Frontiers in Veterinary Science·Elettra FeboAndrea Boari
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisAndre F Carvalho
Jun 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adriano LamaMaria Beatrice Passani
Jul 9, 2021·Cellular & Molecular Biology Letters·Jianan ZhaoJinghua Peng
Aug 8, 2021·International Journal of Molecular Sciences·Mònica AguileraSilvia Melgar
Sep 29, 2021·Science Signaling·J Rafael Montenegro-BurkeDennis W Wolan
Dec 18, 2021·Frontiers in Cellular Neuroscience·Haley A VecchiarelliMatthew N Hill

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
biopsies
biopsy

Software Mentioned

Analyst
NanoString
nSolver
RNAscope
Partek Genomic Suite
Corel Photo Paint
GraphPad Prism
GraphPad
MultiQuant

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.