Members of the miRNA-200 family regulate olfactory neurogenesis

Neuron
Philip S ChoiCatherine Dulac

Abstract

MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K E RogersF L Margolis
Nov 15, 1996·Cell·P MombaertsR Axel
Nov 6, 1998·The Journal of Investigative Dermatology·J ThéluD Dhouailly
Mar 25, 1999·Cell·B MalnicL B Buck
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·V VasioukhinE Fuchs
May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Jul 3, 2002·Nature Reviews. Neuroscience·Nicolas BertrandFrançois Guillemot
Feb 19, 2003·Nature Genetics·Michael NicolasFreddy Radtke
Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Jul 3, 2003·Nature Reviews. Neuroscience·Catherine Dulac, A Thomas Torello
Dec 19, 2003·Nucleic Acids Research·Axel ViselGregor Eichele
Dec 20, 2003·Nature·Robert J Johnston, Oliver Hobert
Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
Mar 3, 2004·Nature·Kevin EgganRudolf Jaenisch
Mar 12, 2004·Genes & Development·John G Doench, Phillip A Sharp
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Junji Hirota, Peter Mombaerts
Jul 9, 2004·Briefings in Functional Genomics & Proteomics·Saulius Sumanas, Jon D Larson
Sep 4, 2004·Genome Biology·Eric A MiskaH Robert Horvitz
Dec 25, 2004·Differentiation; Research in Biological Diversity·Vladimir A Botchkarev, Andreij A Sharov
Mar 19, 2005·Science·Antonio J GiraldezAlexander F Schier
May 28, 2005·Science·Erno WienholdsRonald H A Plasterk
Jun 1, 2005·Experimental Cell Research·Crestina L BeitesAnne L Calof
Jul 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Brian D HarfeClifford J Tabin
Sep 15, 2005·Neuron·Kenneth S Kosik, Anna M Krichevsky
Dec 6, 2005·The Journal of Biological Chemistry·Ji-Yeon LeeLothar Hennighausen
Dec 31, 2005·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Jan 20, 2006·Nature·Gerhard M SchrattMichael E Greenberg
Feb 18, 2006·Science·Antonio J GiraldezAlexander F Schier

❮ Previous
Next ❯

Citations

Feb 12, 2013·Pflügers Archiv : European journal of physiology·Toni R PakNatasha N Mott
Jul 15, 2009·Neuromolecular Medicine·Changmei Liu, Xinyu Zhao
May 6, 2008·Nature Cell Biology·Eric A Miska
Mar 17, 2009·Nature Neuroscience·Li-Chun ChengFiona Doetsch
Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dónal O'Carroll, Anne Schaefer
Aug 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Akihiko YamamotoRobert R H Anholt
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lilach M FriedmanKaren B Avraham
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joseph T Coyle
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stephanie KuhnWalter Marcotti
Oct 5, 2011·The Journal of Biological Chemistry·Manvendra K SinghJonathan A Epstein
Apr 7, 2010·Antioxidants & Redox Signaling·Christoph UferHartmut Kuhn
Jun 17, 2008·Zebrafish·Gerrit Begemann
Dec 14, 2011·Development, Growth & Differentiation·Yuichiro Mishima
Nov 14, 2008·Molecular Pharmacology·Yan Zeng
Jul 29, 2009·Molecular and Cellular Biology·Minh T N LeHarvey F Lodish
Aug 7, 2012·Biochemistry. Biokhimii︠a︡·E V FilatovaP A Slominsky
Mar 25, 2009·Journal of Translational Medicine·Jiaqiang RenDavid F Stroncek
Apr 3, 2014·PloS One·Paulami ChatterjeeDebjani Roy
Sep 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Changgeng PengNilima Prakash
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tigwa H DavisErik M Ullian
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean A Georgi, Thomas A Reh
Oct 1, 2009·Epigenomics·Judy Sng, Michael J Meaney
Nov 29, 2011·Yi chuan = Hereditas·Lei DingChun-Bo Teng
Nov 23, 2013·Cancer Letters·Xiangling FengYaguang Xi
Feb 13, 2014·Cellular and Molecular Life Sciences : CMLS·Olga Barca-Mayo, Davide De Pietri Tonelli
Apr 17, 2013·Cellular and Molecular Life Sciences : CMLS·Ivan ContePaola Bovolenta
Aug 12, 2009·Neuromolecular Medicine·Xuekun Li, Peng Jin
Oct 30, 2009·The International Journal of Neuroscience·S Trivedi, G Ramakrishna
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sarah DecembriniFederico Cremisi
Jul 15, 2015·Inhalation Toxicology·Guifa LiShucai Ling
May 9, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tarek ShalabyMichael A Grotzer
Apr 1, 2009·The Journal of Cell Biology·Alex S FlyntJames G Patton
Jul 24, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Feng XuRanhui Duan
Feb 21, 2016·Developmental Biology·Daichi KawaguchiDennis D M O'Leary
Jan 29, 2016·Protoplasma·Manojit BhattacharyaSang-Soo Lee
Aug 17, 2014·Experimental Neurology·Emily Sun, Yanhong Shi

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Methods Mentioned

BETA
antisense oligonucleotides

Software Mentioned

Mfold
MicroCosm
Protech
miRanda

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