Members of the same pharmacological family are not alike: Different opioids, different consequences, hope for the opioid crisis?

Progress in Neuro-psychopharmacology & Biological Psychiatry
Michael A Emery, Shoshana Eitan

Abstract

Pain management is the specialized medical practice of modulating pain perception and thus easing the suffering and improving the life quality of individuals suffering from painful conditions. Since this requires the modulation of the activity of endogenous systems involved in pain perception, and given the large role that the opioidergic system plays in pain perception, opioids are currently the most effective pain treatment available and are likely to remain relevant for the foreseeable future. This contributes to the rise in opioid use, misuse, and overdose death, which is currently characterized by public health officials in the United States as an epidemic. Historically, the majority of preclinical rodent studies were focused on morphine. This has resulted in our understanding of opioids in general being highly biased by our knowledge of morphine specifically. However, recent in vitro studies suggest that direct extrapolation of research findings from morphine to other opioids is likely to be flawed. Notably, these studies suggest that different opioid analgesics (opioid agonists) engage different downstream signaling effects within the cell, despite binding to and activating the same receptors. This recognition implies th...Continue Reading

Citations

Dec 31, 2019·Clinical and Experimental Pharmacology & Physiology·Thomas AntonySabah H El-Ghaiesh
Mar 14, 2020·Behavioural Pharmacology·Vicente Martínez, Raquel Abalo
Mar 14, 2020·Behavioural Pharmacology·Caitlin A MadisonShoshana Eitan
Mar 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosa Mariana Montiel-RuizEver A Blé-González
Oct 9, 2019·International Journal of Environmental Research and Public Health·Jürgen RehmBundit Sornpaisarn
Mar 25, 2020·Psychological Medicine·Caitlin A Madison, Shoshana Eitan
Oct 7, 2020·Pain and Therapy·Lynn R Webster, Suzanne Karan
Mar 14, 2020·Pharmacology & Therapeutics·Jérôme BusserollesAlain Eschalier
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Shoshana EitanJacob Kuempel
Aug 17, 2021·Dimensions of Critical Care Nursing : DCCN·Cheryl B Hines, Clara R Owings

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