PMID: 6413975Oct 1, 1983Paper

Membership mutation of the genetic code: loss of fitness by tryptophan

Proceedings of the National Academy of Sciences of the United States of America
J T Wong

Abstract

Bacillus subtilis strain QB928, a tryptophan-auxotroph, was serially mutated to yield strain HR15. For QB928, tryptophan functioned as a competent amino acid and 4-fluorotryptophan as merely an inferior analogue. For HR15, these roles were reversed. The tryptophan/4-fluorotryptophan growth ratio decreased by a factor of 2 X 10(4) in the transition from QB928 to HR15.

References

Dec 2, 1977·Science·R Uy, F Wold
Jul 18, 1979·Journal of Molecular Evolution·J T Wong, P M Bronskill
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J T Wong
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J T Wong
Jul 1, 1974·Analytical Biochemistry·B PenkeK Kovács
Apr 8, 1970·Biochemical and Biophysical Research Communications·D R BrowneG D Hegeman
Jan 1, 1970·Annual Review of Genetics·L Gorini
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J E HeckmanU L RajBhandary
Jan 1, 1981·Journal of Molecular Evolution·T H Jukes
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J T Wong
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B G BarrellI G Young
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S G BonitzA Tzagoloff
Nov 22, 1963·Science·R T HINEGARDNER, J ENGELBERG

❮ Previous
Next ❯

Citations

Feb 3, 2007·Applied Microbiology and Biotechnology·Birgit Wiltschi, Nediljko Budisa
Jul 6, 2007·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Jeffrey Tze-Fei Wong
Apr 5, 1984·Biochimica Et Biophysica Acta·M J Wilson, D L Hatfield
May 17, 2006·Trends in Ecology & Evolution·Jamie M BacherAndrew D Ellington
Jun 24, 2010·Nucleic Acids Research·Randall A Hughes, Andrew D Ellington
Dec 24, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David H Ardell, Guy Sella
Aug 15, 1986·European Journal of Biochemistry·J T Wong, R Cedergren
Jun 11, 2004·Annual Review of Biochemistry·Tamara L HendricksonPaul Schimmel
Dec 12, 2003·BMC Evolutionary Biology·Jamie M BacherAndrew D Ellington
Sep 3, 2010·PloS One·Wai-Kin MatJ Tze-Fei Wong
Feb 28, 2014·Genome Biology and Evolution·Allen Chi-Shing YuTing-Fung Chan
Nov 30, 2013·Applied Microbiology and Biotechnology·Allen C S YuTing-Fung Chan
Jan 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Randall A Hughes, Andrew D Ellington
Sep 1, 1989·Journal of Molecular Evolution·M Di Giulio
Jan 19, 2016·Nature Chemical Biology·Drew S TackAndrew D Ellington
Sep 9, 2015·Journal of Molecular Biology·M J LajoieG M Church
Jan 2, 2009·IUBMB Life·Eugene V Koonin, Artem S Novozhilov
Jun 5, 2004·Gene·Ka-Lok Tong, J Tze-Fei Wong
Aug 18, 2001·Current Biology : CB·M IbbaD Söll
Dec 28, 2010·Current Opinion in Chemical Biology·Eric M Brustad, Frances H Arnold
Aug 5, 2016·Microbial Biotechnology·Carlos G Acevedo-Rocha, Nediljko Budisa
Jun 25, 2005·Chemistry & Biology·Jason Micklefield
Jan 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Brian K Davis
Jun 29, 2002·Nature Biotechnology·Koji Tamura, Paul Schimmel
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Tze-Fei Wong
Feb 21, 2018·Scientific Reports·Drew S TackAndrew D Ellington
Jan 16, 2010·Angewandte Chemie·Bastian HolzbergerAndreas Marx
Jan 14, 2017·Angewandte Chemie·Federica AgostiniNediljko Budisa
Apr 24, 2020·Chembiochem : a European Journal of Chemical Biology·Nediljko BudisaMarkus Schmidt
Apr 11, 2020·Chembiochem : a European Journal of Chemical Biology·Manuel Nieto-Domínguez, Pablo I Nikel
Jul 3, 2015·Angewandte Chemie·Michael Georg HoeslNediljko Budisa
Mar 8, 2017·Life·Hong Xue, J Tze-Fei Wong
Mar 25, 2017·Life·Xiao LinTing Fung Chan
Aug 26, 2015·Chembiochem : a European Journal of Chemical Biology·Carlos G Acevedo-Rocha, Dirk Schulze-Makuch
May 24, 2020·Nature Chemical Biology·Mary S MorrisonDavid R Liu
May 15, 2019·International Journal of Molecular Sciences·Tobias BaumannNediljko Budisa
Sep 17, 2020·Natural Product Reports·Manuel Montalbán-LópezWilfred A van der Donk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.