PMID: 2622865Nov 1, 1989Paper

Membrane actions of ethanol on rabbit sino-atrial node studied by voltage clamp method

Pharmacology & Toxicology
H KotakeH Mashiba


Electrophysiological effects of ethanol on rabbit sino-atrial node were studied by means of the double-microelectrode voltage clamp method. In spontaneously beating preparations, ethanol (above 1%) decreased the maximum rate of depolarization of the action potential. Furthermore, 3% ethanol produced a significant decrease in the action potential amplitude, the action potential duration at 50% repolarization and the rate of the diastolic depolarization. Of the current systems, voltage clamp studies showed that ethanol reduced the slow inward current, the time-dependent potassium outward current and the hyperpolarization activated inward current. These observations indicate that ethanol does not have an effect on a single current system, but directly modifies the spontaneous discharge of sino-atrial node pacemaker cells due to a reduction of the time-dependent current systems.


Apr 1, 1978·Physiological Reviews·H Irisawa
Sep 1, 1979·Pflügers Archiv : European journal of physiology·A NomaW Trautwein
Jan 1, 1978·The Journal of Physiology·T F McDonald, W Trautwein
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Mar 1, 1988·Japanese Circulation Journal·H KotakeH Mashiba
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