Membrane and soluble ILT3 are critical to the generation of T suppressor cells and induction of immunological tolerance

International Reviews of Immunology
George VladNicole Suciu-Foca

Abstract

The tolerogenic phenotype of human dendritic cells is characterized by high cell surface expression of the inhibitory receptor ILT3. ILT3 signals both intracellularly inhibiting tyrosine phosphorylation, NF-kappaB and MAPK p38 activity, transcription of certain co-stimulatory molecules, secretion of cytokines and chemokines, and extracellularly into the T cells with which the dendritic cells interact. Both ILT3(high) tolerogenic dendritic cells and soluble ILT3 induce CD4 Th anergy and differentiation of antigen specific CD8 T suppressor cells. Recombinant ILT3-Fc protein has important immunotherapeutic potential acting directly on activated T cells and promoting the induction of immunological tolerance.

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Citations

Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jacques BanchereauEynav Klechevsky
Apr 9, 2016·Journal of Immunology Research·Paola Del Carmen Guerra-de BlasAdriana Elizabeth Monsiváis-Urenda
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Feb 2, 2020·Journal of Hematology & Oncology·Zhenzhen YangWang Ma
Jul 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masakatsu SuzukiCornelia M Weyand

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