Membrane associated functions of neurokinin B (NKB) on Abeta (25-35) induced toxicity in aging rat brain synaptosomes

Biogerontology
Anil K ManthaNajma Zaheer Baquer

Abstract

The effect of different concentrations (0.1-5 microM) of neurokinin B (NKB) and Abeta (25-35) on acetylcholine esterase (AChE), Na(+)-K(+) ATPase and membrane fluidity (DPH anisotropy) were investigated in rat brain synaptosomes of 3, 9, 18 and 30 months old. An age dependent decrease was observed for all the three parameters studied. An in vitro incubation of isolated brain synaptosomes with Abeta (25-35) showed toxic effects on all the parameters studied and the peptide had concentration and age dependent effects, while NKB showed stimulating effect on the parameters and the combined NKB+Abeta (25-35) incubations showed a partial reversal effect as compared to the Abeta (25-35) alone. Thus, the results suggest a membrane mediated function for NKB and its role in neuromodulation, neuroprotection and antioxidant property against Abeta (25-35) induced toxicity in aging brain functions.

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Citations

Apr 22, 2009·Biogerontology·Najma Z BaquerDeepak Sharma
Aug 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maria A de Souza SilvaSandra Schäble
Aug 2, 2011·Neuroscience Letters·Pardeep KumarNajma Zaheer Baquer
Feb 24, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S SchäbleM A de Souza Silva
Mar 8, 2011·Experimental Gerontology·Pardeep KumarNajma Zaheer Baquer
May 2, 2013·Journal of Neuroendocrinology·R WongC L Gibson
Feb 17, 2015·Journal of Biochemical and Molecular Toxicology·Saeed SamarghandianFatemeh Karimnezhad
Jan 3, 2012·Neurobiology of Learning and Memory·Sandra SchäbleMaria A de Souza Silva
Oct 17, 2012·Neurochemistry International·Fudong Liu, Louise D McCullough
Apr 20, 2021·Biological Psychiatry·A Shaam Al AbedNathalie Dehorter
Sep 15, 2020·ACS Chemical Neuroscience·Wen-Wen ZhangYu-Xia Chu

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