PMID: 3768414Oct 29, 1986Paper

Membrane-associated protein kinases in phorbol ester-activated human polymorphonuclear leukocytes

Biochimica Et Biophysica Acta
N O ChristiansenV Esmann

Abstract

Membrane-associated protein kinases in human polymorphonuclear leukocytes were studied. In unstimulated polymorphonuclear leukocytes the protein kinase C was predominantly present in the cytosol but in phorbol 12-myristate 13-acetate- (PMA-) activated cells a time and dose-dependent translocation of the kinase to the particulate fraction occurred. Two new protein kinase activities also appeared in the particulate fraction upon PMA activation. The one had a Mr of 40,000 and its activity was independent of phospholipids. The other (Mr 90,000) as partially activated by phospholipids, but separated from protein kinase C on DEAE-cellulose chromatography.

References

May 2, 1985·European Journal of Biochemistry·G SkoglundM Ingelman-Sundberg
Feb 21, 1986·Biochimica Et Biophysica Acta·N O Christiansen, H Juhl
May 16, 1984·Biochemical and Biophysical Research Communications·A Rodriguez-Pena, E Rozengurt
Jul 29, 1983·Biochemical and Biophysical Research Communications·R I Sha'afiM B Feinstein
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·H RozenbergZ Shakked
Apr 1, 1964·Metabolism: Clinical and Experimental·V ESMANN

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Citations

Aug 1, 1989·Agents and Actions·T HerlinK Kragballe
Sep 15, 1987·Biochemical and Biophysical Research Communications·N O ChristiansenV Esmann
Nov 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M KöllerW König
May 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·D ObelN O Christiansen
Apr 1, 1989·Scandinavian Journal of Immunology·N O Christiansen, N Borregaard
Jan 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·P N Bouchelouche, D Berild
May 13, 1988·Biochimica Et Biophysica Acta·C S LarsenV Esmann

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