Membrane binding domains.

Biochimica Et Biophysica Acta
James H Hurley

Abstract

Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes.

Citations

Jun 9, 2007·Journal of Mammary Gland Biology and Neoplasia·Dmitriy KedrinJeffrey E Segall
Jun 19, 2010·Nature Chemical Biology·Tatiana G Kutateladze
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Evzen Boura, James H Hurley
Aug 3, 2012·The Journal of Biological Chemistry·Sónia Troeira HenriquesDavid J Craik
Sep 21, 2006·The Journal of Biological Chemistry·Stephanie A LeeTatiana G Kutateladze
May 29, 2013·The Journal of General Physiology·Radda RusinovaOlaf S Andersen
Oct 5, 2007·Molecular Biology of the Cell·Satoe Takahashi, Peter M Pryciak
Aug 28, 2009·Molecular Biology of the Cell·Patrik ErlmannMonilola A Olayioye
Nov 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Alexandra C Newton
Jan 16, 2009·Journal of Lipid Research·Koen Temmerman, Walter Nickel
Nov 27, 2008·Journal of Lipid Research·Alexandra C Newton
Nov 15, 2008·Journal of Lipid Research·Robert V Stahelin
Jul 9, 2011·PloS One·Robert C Wells, R Blake Hill
Jul 25, 2014·BioMed Research International·Katerina C NastouStavros J Hamodrakas
Nov 14, 2013·Chemistry and Physics of Lipids·Michael D Best
Feb 22, 2014·Chemistry and Physics of Lipids·Robert V StahelinCary T Frick
May 16, 2012·Molecular Membrane Biology·John M Sanderson
Jul 1, 2008·Expert Opinion on Drug Discovery·Stephen HarrisonDirk Mendel
Jul 31, 2014·Journal of the American Chemical Society·Jianing LiGregory A Voth
Jul 28, 2009·Archives of Biochemistry and Biophysics·Maria C Pérez-GordonesGustavo Benaim
Dec 8, 2015·Scientific Reports·Grace CampagnolaDiego Krapf
Mar 27, 2007·Biochimica Et Biophysica Acta·Thomas Strahl, Jeremy Thorner
Feb 27, 2007·Biochimica Et Biophysica Acta·Rhoderick E Brown, Peter Mattjus
Aug 23, 2008·IUBMB Life·Lisa L Gallegos, Alexandra C Newton
May 15, 2013·The FEBS Journal·Annie Quan, Phillip J Robinson
Feb 1, 2012·Cellular Microbiology·Thomas JankKlaus Aktories
Jul 11, 2008·Brain Research·Xuefeng DingMing Fan

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