PMID: 15388891Sep 25, 2004Paper

Membrane-bound macrophage colony-stimulating factor mediated auto-juxtacrine downregulates matrix metalloproteinase-9 release on J6-1 leukemic cell

Experimental Biology and Medicine
Qing RaoKe-Fu Wu

Abstract

Earlier studies indicate that J6-1 human leukemic cells proliferate and propagate via the membrane-bound macrophage colony-stimulating factor (M-CSF)-mediated auto-juxtacrine mechanism. Matrix metalloproteinases (MMPs) can modulate the activity of cell membrane molecules and influence many cellular behaviors. Therefore, we hypothesized that MMP may also be involved in the membrane-bound M-CSF-mediated juxtacrine mechanism. First, we investigated whether blocking of membrane-bound M-CSF by neutralizing antibody to M-CSF or M-CSF receptor and adding of exogenous M-CSF are able to influence MMP-9 release. Next, we determined whether MMP-9 participated in J6-1 cells proliferation and influence the shedding of membrane-bound M-CSF and its receptor. Current studies show that blockade of the interaction between membrane-bound M-CSF and M-CSF receptor by antibody to M-CSF or M-CSF receptor promotes MMP-9 release. Moreover, we demonstrated that because of M-CSF mediated juxtacrine, lack of MMP-9 promotes J6-1 cell proliferation, in which a decrease in the shedding of cell-surface M-CSFR is involved. Hence, we suggest that membrane-bound M-CSF inhibit MMP-9 release and down-regulated MMP-9 contribute to juxtacrine stimulating in leukemic...Continue Reading

References

Jan 1, 1990·Leukemia Research·M R ParwareschH J Radzun
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Feb 1, 1995·Cytokine·A MackiewiczS Rose-John
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Aug 23, 2000·The Journal of Clinical Investigation·S DiasS Rafii
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D BaramY A Mekori

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Citations

Jan 25, 2018·Immunology and Cell Biology·Rong WangGuoguang Zheng
Aug 9, 2008·International Immunopharmacology·Thomas G DouglassMartin R Jadus

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