Membrane composition variation and underdamped mechanics near transmembrane proteins and coats

Physical Review Letters
S Alex RautuMatthew S Turner

Abstract

We study the effect of transmembrane proteins on the shape, composition, and thermodynamic stability of the surrounding membrane. When the coupling between membrane composition and curvature is strong enough, the nearby membrane composition and shape both undergo a transition from overdamped to underdamped spatial variation, well before the membrane becomes unstable in the bulk. This transition is associated with a change in the sign of the thermodynamic energy and, hence, favors the early stages of coat assembly necessary for vesiculation (budding) and may suppress the activity of mechanosensitive membrane channels and transporters. Our results suggest an approach to obtain physical parameters of the membrane that are otherwise difficult to measure.

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Citations

Oct 24, 2019·Physical Review. E·Piermarco FondaLuca Giomi
Mar 20, 2018·Physical Review. E·S Alex Rautu
Jul 9, 2016·Physical Review Letters·Benedikt Sabass, Howard A Stone
Jan 21, 2021·Physical Review. E·Ahis ShresthaChristoph A Haselwandter
Mar 13, 2021·Physical Review Letters·Marco ZamparoAndrea Gamba

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