Membrane curvature induced by aggregates of LH2s and monomeric LH1s.

Biophysical Journal
Danielle E ChandlerKlaus Schulten

Abstract

The photosynthetic apparatus of purple bacteria is contained within organelles called chromatophores, which form as extensions of the cytoplasmic membrane. The shape of these chromatophores can be spherical (as in Rhodobacter sphaeroides), lamellar (as in Rhodopseudomonas acidophila and Phaeospirillum molischianum), or tubular (as in certain Rb. sphaeroides mutants). Chromatophore shape is thought to be influenced by the integral membrane proteins Light Harvesting Complexes I and II (LH1 and LH2), which pack tightly together in the chromatophore. It has been suggested that the shape of LH2, together with its close packing in the membrane, induces membrane curvature. The mechanism of LH2-induced curvature is explored via molecular dynamics simulations of multiple LH2 complexes in a membrane patch. LH2s from three species-Rb. sphaeroides, Rps. acidophila, and Phsp. molischianum-were simulated in different packing arrangements. In each case, the LH2s pack together and tilt with respect to neighboring LH2s in a way that produces an overall curvature. This curvature appears to be driven by a combination of LH2's shape and electrostatic forces that are modulated by the presence of well-conserved cytoplasmic charged residues, the remo...Continue Reading

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Citations

Apr 9, 2013·Trends in Plant Science·Lu-Ning Liu, Simon Scheuring
Sep 15, 2010·PLoS Computational Biology·Neeraj J AgrawalRavi Radhakrishnan
Jul 17, 2014·The Journal of Chemical Physics·Martina PannuzzoRainer A Böckmann
Aug 28, 2010·Journal of Structural Biology·Lu-Ning LiuSimon Scheuring
Jun 5, 2012·Biochimica Et Biophysica Acta·Peter G Adams, C Neil Hunter
Oct 12, 2010·Journal of Structural Biology·Leonardo G TrabucoKlaus Schulten
Apr 2, 2014·Biochimica Et Biophysica Acta·Simon ScheuringZiv Reich
Jun 5, 2014·Biophysical Journal·Danielle E ChandlerKlaus Schulten
Aug 27, 2016·ELife·Melih SenerKlaus Schulten
Nov 7, 2018·Physical Chemistry Chemical Physics : PCCP·Kai YangBing Yuan
Feb 26, 2010·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jen HsinKlaus Schulten
Feb 24, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Melih ŞenerKlaus Schulten
Jul 22, 2015·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Kristyna Pluhackova, Rainer A Böckmann

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