Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.

Proceedings of the National Academy of Sciences of the United States of America
Maarten F M EngelJo W M Höppener

Abstract

Fibrillar protein deposits (amyloid) in the pancreatic islets of Langerhans are thought to be involved in death of the insulin-producing islet beta cells in type 2 diabetes mellitus. It has been suggested that the mechanism of this beta cell death involves membrane disruption by human islet amyloid polypeptide (hIAPP), the major constituent of islet amyloid. However, the molecular mechanism of hIAPP-induced membrane disruption is not known. Here, we propose a hypothesis that growth of hIAPP fibrils at the membrane causes membrane damage. We studied the kinetics of hIAPP-induced membrane damage in relation to hIAPP fibril growth and found that the kinetic profile of hIAPP-induced membrane damage is characterized by a lag phase and a sigmoidal transition, which matches the kinetic profile of hIAPP fibril growth. The observation that seeding accelerates membrane damage supports the hypothesis. In addition, variables that are well known to affect hIAPP fibril formation, i.e., the presence of a fibril formation inhibitor, hIAPP concentration, and lipid composition, were found to have the same effect on hIAPP-induced membrane damage. Furthermore, electron microscopy analysis showed that hIAPP fibrils line the surface of distorted pho...Continue Reading

References

Jun 25, 1985·Journal of Molecular Biology·F A FerroneW A Eaton
Mar 20, 1973·Virchows Archiv. A: Pathology. Pathologische Anatomie·P Westermark
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N ArispeE Rojas
Jan 26, 1996·The Journal of Biological Chemistry·T A MirzabekovB L Kagan
May 11, 1999·The American Journal of Pathology·H J Hiddinga, N L Eberhardt
Aug 10, 2000·The New England Journal of Medicine·J W HöppenerC J Lips
Aug 15, 2000·Journal of Structural Biology·C GoldsburyU Aebi
Oct 4, 2000·Nature Structural Biology·J W Kelly
Dec 17, 2003·Neurobiology of Aging·Annemieke A M RensinkBerry Kremer
Jan 20, 2004·Journal of Molecular Biology·O Sumner Makin, Louise C Serpell
Jan 31, 2004·The Journal of Biological Chemistry·Brian O'NuallainRonald Wetzel
Aug 11, 2004·Biochemistry·Hongxia ZhaoPaavo K J Kinnunen
Aug 24, 2004·Journal of Molecular Biology·Jefferson D Knight, Andrew D Miranker
Feb 22, 2005·The Journal of Biological Chemistry·Angelo DemuroCharles G Glabe
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gerald P GellermannMarcus Fändrich
Jul 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Arjan QuistRatnesh Lal
Sep 7, 2005·Biochemistry·Sajith A Jayasinghe, Ralf Langen
Jan 13, 2006·Journal of Molecular Biology·Maarten F M EngelJ Antoinette Killian
Mar 24, 2006·The Journal of Biological Chemistry·Vera NovitskayaIlia V Baskakov
Jul 20, 2006·American Journal of Physiology. Endocrinology and Metabolism·Juris J MeierPeter C Butler
Dec 1, 2006·Journal of Molecular Biology·Anna L GharibyanLudmilla A Morozova-Roche
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amy M Ruschak, Andrew D Miranker

❮ Previous
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Citations

Jan 7, 2010·European Biophysics Journal : EBJ·Lucie KhemtémourianJ Antoinette Killian
Apr 24, 2010·Apoptosis : an International Journal on Programmed Cell Death·Chun-Yung HuangShu-Mei Liang
Apr 27, 2013·Journal of Bioenergetics and Biomembranes·Daniela MeleleoGabriella Notarachille
Nov 1, 2008·Cell Biochemistry and Biophysics·Roberth ByströmGerhard Gröbner
Jan 22, 2014·International Journal of Biological Macromolecules·Maria-Magdalena MocanuZuzana Gazova
Sep 29, 2011·Accounts of Chemical Research·Jeffrey R BrenderAyyalusamy Ramamoorthy
May 9, 2012·Biochemistry·Gai LiuNoel D Lazo
Sep 14, 2012·Biochemistry·Michele F M SciaccaAyyalusamy Ramamoorthy
Nov 8, 2008·Biochemistry·Ravi Prakash Reddy NangaAyyalusamy Ramamoorthy
Sep 16, 2011·Journal of the American Chemical Society·Lu WangJames L Skinner
Aug 30, 2011·Journal of the American Chemical Society·Lucie KhemtémourianJ Antoinette Killian
Oct 18, 2011·Journal of the American Chemical Society·Corianne C vandenAkkerGijsje H Koenderink
Jul 19, 2013·Journal of the American Chemical Society·Katrine Kirkeby SkebyBirgit Schiøtt
Mar 13, 2009·Journal of the American Chemical Society·Pieter E S SmithAyyalusamy Ramamoorthy
Mar 17, 2011·The Journal of Physical Chemistry. B·L WangJ L Skinner
Mar 17, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ha Phuong TaSophie Lecomte
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sang-Hee ShimMartin T Zanni
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lilia MilanesiHelen R Saibil
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicholas B Last, Andrew D Miranker
Jun 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anthony W P FitzpatrickAhmed H Zewail
Oct 8, 2009·The Journal of Biological Chemistry·Wei-Feng XueSheena E Radford
Aug 26, 2011·The Journal of Biological Chemistry·Saurabh Trikha, Aleksandar M Jeremic
Nov 7, 2012·The Journal of Biological Chemistry·Katharina FlachMax Holzer
Oct 5, 2010·Journal of Biochemistry·Chai L TeohGeoffrey J Howlett
Jul 13, 2012·Journal of the Royal Society, Interface·Shanghao LiRoger M Leblanc
Jan 10, 2009·BMC Biotechnology·Chun-Yung HuangShu-Mei Liang
Apr 11, 2009·PLoS Computational Biology·Ping JiangYuguang Mu
Sep 17, 2013·International Journal of Molecular Sciences·Stefania GaldieroMassimiliano Galdiero
Apr 23, 2013·BioMed Research International·Karen Pillay, Patrick Govender
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ping CaoDaniel P Raleigh
Nov 10, 2013·Advances in Colloid and Interface Science·Annalisa ReliniAlessandra Gliozzi

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