Membrane damage to bacteria caused by single and combined biocides

Journal of Applied Microbiology
M D JohnstonR J W Lambert

Abstract

To examine the effect on the leakage of low molecular weight cytoplasmic constituents from Staphylococcus aureus using phenolics singly and in combination, and to see if the observations could be modelled using a non-linear dose response. The rate of potassium, phosphate and adenosine triphosphate leakage was examined in the presence of chlorocresol and m-cresol. Individually, leakage was observed only at long contact times or high concentrations. Combined at these ineffective concentrations, the cytoplasmic pool of all constituents studied was released within minutes. Both chlorocresol and m-cresol were shown to have non-linear dose responses. A rate model for the combinations, which takes account of these non-linear responses, accurately predicted the observations. Antimicrobials, which when used alone exhibit a non-linear dose response, will also give a non-linear dose response in combination. The simple linear-additive model ignores the concept of the dilution coefficient and will always describe the phenomenon of synergy for combinations where one or more of the components has a dilution coefficient greater than one. This has been borne out by examination of the purported prime lesion of chlorocresol and m-cresol, alone an...Continue Reading

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Citations

Sep 9, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Z Stojanović-RadićT Mihajilov-Krstev
Oct 20, 2012·Journal of Industrial Microbiology & Biotechnology·Mohammad SalmaHervé Alexandre
Jul 12, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Eunkyung JiDavid G Whitten
Mar 14, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Anabela BorgesManuel Simões
Jul 23, 2004·Expert Opinion on Investigational Drugs·Alex J O'Neill, Ian Chopra
Sep 8, 2009·International Journal of Food Microbiology·F M CamposT A Hogg
Jan 16, 2004·Journal of Applied Microbiology·R J W LambertS P Denyer
Jul 16, 2008·Letters in Applied Microbiology·M-K WeiJ-M Zhang
Jul 28, 2011·Journal of Applied Microbiology·Y Q ZhangX H Yang
Sep 29, 2012·Journal of Medical Microbiology·Sean ConnellRiyi Shi
Aug 12, 2014·International Journal of Food Microbiology·Rinrada PattanayaiyingCatherine N Cutter
Mar 13, 2003·Journal of Applied Microbiology·R J W LambertS P Denyer
Apr 19, 2015·BMC Complementary and Alternative Medicine·David A AkinpeluAnthony I Okoh
Feb 8, 2011·International Journal of Food Microbiology·Almudena García-RuizBegoña Bartolomé
Nov 9, 2004·The Journal of Antimicrobial Chemotherapy·Alexander John O'NeillIan Chopra
Nov 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana F MalheiroManuel Simões
Oct 4, 2019·Scientific Reports·Jordan ChamberlinDev P Arya
Dec 14, 2018·Journal of Medical Microbiology·Gerard SheehanKevin Kavanagh
Jul 24, 2020·Pakistan Journal of Biological Sciences : PJBS·Kusavadee SangdeePrasong Srihanam
Jul 4, 2020·AIMS Microbiology·Awatif A Al-Judaibi
Jun 23, 2019·BMC Complementary and Alternative Medicine·María C SánchezDavid Herrera
Aug 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Sireesha ChemburuDavid G Whitten
Jun 22, 2021·Frontiers in Microbiology·Olajumoke A OlatejuIruka N Okeke

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