Membrane defect and energy status of rabbit skeletal muscle cells in sepsis and septic shock

Archives of Surgery
H P Illner, G T Shires

Abstract

Measurements of the resting membrane potential in skeletal muscle were used to monitor cell function in live Escherichia coli-induced sepsis and septic shock. Depolarization of the cell membrane, indicative of cell swelling, occurred before the onset of deep hypotension, suggesting cellular injury as a primary cause rather than a result of shock. The normal values for high-energy phosphates found in skeletal muscle in the terminal stages of shock reduce the possibility of an energy deficit as one of the factors in the cellular membrane malfunctions in septic shock.

Citations

Sep 29, 2005·Intensive Care Medicine·Sophie LanoneMichel Aubier
Oct 1, 1986·The Journal of Experimental Medicine·K J TraceyG T Shires
Mar 1, 1994·Annals of Surgery·B J EastridgeD S Gann
Jul 1, 1986·The Proceedings of the Nutrition Society·M J McMahon
Aug 26, 2014·Critical Care : the Official Journal of the Critical Care Forum·Karin A AckermannWerner J Z'Graggen
Jan 1, 1989·The Journal of Surgical Research·S ShionoG T Shires
Jan 28, 2005·The Journal of Trauma·Daniel N Darlington, Donald S Gann
May 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S K SongJ J Ackerman
Sep 28, 2001·British Journal of Anaesthesia·B AllaouchicheD Chassard
Nov 1, 1987·Seikagaku. The Journal of Japanese Biochemical Society·M Kawakami
Feb 1, 1995·Critical Care Medicine·G GutierrezE Fernandez
Aug 1, 1995·The Journal of Trauma·B D BorcheltD S Gann
May 28, 2005·The Journal of Trauma·Daniel N Darlington, Donald S Gann
Jan 6, 2006·The Journal of Trauma·Daniel N Darlington, Donald S Gann
Jul 3, 2015·Physiological Reviews·O FriedrichL Larsson
Nov 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·Y FongA Cerami
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·M C LinB J Petrof
May 1, 1997·The American Journal of Physiology·P A SchornackJ J Ackerman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.