Membrane detachment is not essential for COG complex function.

Molecular Biology of the Cell
Leslie K ClimerVladimir V Lupashin

Abstract

COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.

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Citations

Aug 6, 2019·FEBS Letters·Jessica B BlackburnVladimir V Lupashin
Jul 25, 2019·Frontiers in Cell and Developmental Biology·Zinia D'SouzaVladimir V Lupashin
Jul 8, 2020·International Journal of Molecular Sciences·Peter T A LindersGeert van den Bogaart
Jul 8, 2020·Viruses·Susan RealegenoPanayampalli Subbian Satheshkumar
Jul 31, 2020·Biochimica Et Biophysica Acta. General Subjects·Zinia D'SouzaVladimir V Lupashin

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Datasets Mentioned

BETA
GM130

Methods Mentioned

BETA
glycosylation
electron microscopy
coimmunoprecipitation
FACS
superresolution
fluorescence microscopy
superresolution microscopy
Pull down
pull-down
pull downs

Software Mentioned

Zen
TEM Imaging and Analysis
Elyra
ZEN colocalization

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