Membrane dynamics shape TCR-generated signaling.

Frontiers in Immunology
Hai-Tao He, Pierre Bongrand

Abstract

Despite intensive investigation, the mechanisms of T cell receptor (TCR)-mediated signal generation remain poorly understood. Here we review various dynamic processes at the cell membrane that might critically control this signaling. Firstly, we summarize recent reports providing new information on the sensitivity of TCR/ligand interaction to the membrane environment and particularly to applied forces. Secondly, we review recent evidence that forces and displacements are continuously generated at cell surfaces. Thirdly, we summarize recent experimental evidence demonstrating the capacity of forces to generate signals. Lastly, we provide a quantitative model to exemplify the capacity of dynamic processes to modulate TCR properties such as specificity that were previously difficult to explain with conventional models. It is concluded that the described dynamic processes must be integrated into current models of TCR signaling.

Citations

Dec 4, 2014·Trends in Immunology·Itamar KassNatalie A Borg
Feb 26, 2016·Frontiers in Immunology·Claire Hivroz, Michael Saitakis
Jul 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Laurent LimozinPhilippe Robert
Mar 18, 2015·European Journal of Immunology·Alexandre BrodovitchPhilip Anton van der Merwe
Jul 31, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre BrodovitchAnne Pierres
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abigail H PollockKatharina Gaus
Apr 25, 2018·Frontiers in Immunology·Mohammad Ameen Al-AghbarSteve R Roffler
Dec 25, 2019·Biochimica Et Biophysica Acta. Biomembranes·Rhiannon L Brooks, Ann M Dixon
Apr 12, 2015·Annual Review of Immunology·Bernard Malissen, Pierre Bongrand

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Methods Mentioned

BETA
atomic force microscopy
optical tweezers

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