Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins.

Biophysical Journal
D MarshJörg H Kleinschmidt

Abstract

Folding of porin-like beta-barrel outer membrane proteins can be achieved in the presence of phospholipid vesicles, and takes place concurrently with incorporation into the membrane. The pronounced dependence found for the insertion of the protein OmpA on membrane thickness (Kleinschmidt, J. H., and L. K. Tamm. 2002. J. Mol. Biol. 324:319-330) is analyzed in terms of the effects of out-of-plane elastic fluctuations on the area dilation modulus (Evans, E., and W. Rawicz. 1990. Phys. Rev. Lett. 64:2094-2097). For unstrained large unilamellar vesicles, the elastic free energy for membrane insertion is predicted to depend on the fourth power of the membrane thickness. The influence of thermally induced bending fluctuations on the effective tilt of the OmpA beta-barrel in disaturated phosphatidylcholine membranes of different thicknesses (Ramakrishnan, M., J. Qu, C. L. Pocanschi, J. H. Kleinschmidt, and D. Marsh. 2005. Biochemistry. 44:3515-3523) is also considered. A contribution to the orientational order parameter that scales as the inverse second power of the membrane thickness is predicted.

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Surrey, F Jähnig
Sep 1, 1974·Zeitschrift Für Naturforschung. Section C: Biosciences·W Helfrich
Nov 24, 1995·The Journal of Biological Chemistry·T Surrey, F Jähnig
Oct 29, 1996·Biochimica Et Biophysica Acta·D Marsh
Jun 1, 1997·Biophysical Journal·D Marsh
Nov 10, 1998·Nature Structural Biology·A Pautsch, G E Schulz
Apr 23, 1990·Physical Review Letters·E Evans, W Rawicz
Jun 27, 2000·Biophysical Journal·W RawiczE Evans
Nov 7, 2000·Biochimica Et Biophysica Acta·J F Nagle, S Tristram-Nagle
Jan 11, 2001·Protein Science : a Publication of the Protein Society·K DoringF Jähnig
Mar 29, 2001·Nature Structural Biology·A AroraL K Tamm
Jul 19, 2002·Biophysical Journal·Jörg H Kleinschmidt, Lukas K Tamm
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Heedeok Hong, Lukas K Tamm

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Citations

Feb 2, 2013·European Biophysics Journal : EBJ·Cosmin L PocanschiJörg H Kleinschmidt
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Francisco N BarreraDonald M Engelman
Nov 27, 2009·Canadian Journal of Microbiology·Denice C Bay, Deborah A Court
May 24, 2014·Biochimica Et Biophysica Acta·Daniel Koller, Karl Lohner
Oct 19, 2006·Chemistry and Physics of Lipids·Derek Marsh
May 24, 2011·Biochimica Et Biophysica Acta·Mun'delanji C VestergaardMasahiro Takagi
Mar 1, 2011·Biophysical Journal·Jeffrey F EllenaDavid S Cafiso
Aug 8, 2006·Biophysical Journal·Cosmin L PocanschiJörg H Kleinschmidt
Feb 26, 2008·Biochimica Et Biophysica Acta·Derek Marsh
Dec 23, 2017·BMC Biology·Bob SchiffrinSheena E Radford
May 11, 2016·Journal of Bacteriology·Tara F MahoneyThomas J Silhavy
Feb 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Miranda L JacobsNeha P Kamat
Oct 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joe SarkisJean-François Hubert
Jun 6, 2020·The Journal of Biological Chemistry·Jim E HorneSheena E Radford
Aug 9, 2018·Proceedings of the National Academy of Sciences of the United States of America·Karl LundquistJames C Gumbart
Dec 16, 2018·Nature Communications·Anaïs MennyDoryen Bubeck
Nov 8, 2012·Archives of Biochemistry and Biophysics·Daniel E Otzen, Kell K Andersen
Jul 6, 2014·Biochemistry·Wolfgang GrosseLars-Oliver Essen
Jan 13, 2012·Biochimica Et Biophysica Acta·Drake C Mitchell

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