PMID: 2852263Nov 1, 1988Paper

Membrane fluidity of erythrocytes and its relevance to renin profile in essential hypertension

Japanese Circulation Journal
K TsudaI Nishio

Abstract

This study was performed to investigate the membrane fluidity of hypertension by means of an electron spin resonance (E.S.R.) and a spin-labeling technique. Erythrocytes from patients with untreated essential hypertension (WHO I, II) and secondary hypertension were compared with those from normotensive subjects, and E.S.R. spectra for a fatty acid spin label agent (5-nitroxy stearate) incorporated into the erythrocyte membranes were obtained. The values of outer hyperfine splitting (2T'parallel) and order parameter (S) were significantly higher in erythrocytes from patients with essential hypertension than in those from normotensive subjects. However, these values were not significantly changed in patients with secondary hypertension compared with those in the normotensive subjects. This finding may indicate the reduced erythrocyte membrane fluidity in essential hypertension. Calcium-loading to erythrocytes with calcium-ionophore caused a greater decrease in the membrane fluidity of erythrocytes in patients with essential hypertension than in those from the normotensive subjects. This Ca-induced change in membrane fluidity was inversely correlated with plasma renin activity in essential hypertension. In addition, changes in mem...Continue Reading

Citations

Oct 28, 2006·Biochimica Et Biophysica Acta·Pablo V EscribáOliver Vögler
Nov 2, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazushi Tsuda
Nov 15, 2000·American Journal of Hypertension·A McLauren DorranceR Fraser

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