Membrane Fusion Stalks and Lipid Rafts: A Love-Hate Relationship

Biophysical Journal
Herre Jelger Risselada

Abstract

Coarse-grained molecular dynamics simulations are applied to explore the experimentally observed ability of the liquid-ordered (lo)/liquid-disordered (ld) phase boundary to facilitate viral membrane fusion. Surprisingly, a formed fusion stalk can be both attracted (i.e., stalkophilic) and repelled (i.e., stalkophobic) by the lo/ld phase boundary. The phase boundary becomes stalkophilic if the lo phase constituents have the larger negative spontaneous curvature. In such a case, location of the highly curved stalk near the less-ordered and thus (relatively) softer boundary region becomes energetically favorable. These insights may explain why modeled viral fusion occurs preferentially near the lo/ld phase boundary.

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Citations

Oct 10, 2019·Angewandte Chemie·Justin A PeruzziNeha P Kamat
Dec 20, 2020·European Biophysics Journal : EBJ·H Jelger Risselada, Helmut Grubmüller
Feb 23, 2021·Frontiers in Microbiology·Inés RipaRaquel Bello-Morales
Oct 19, 2017·Biophysical Journal·Alex J B KreutzbergerLukas K Tamm
Apr 23, 2021·Biophysical Journal·Chenyu Wei, Andrew Pohorille
Jun 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Marta Salvador-CastellJudith Peters
Jan 10, 2019·Chemical Reviews·Siewert J MarrinkMark S P Sansom
Feb 14, 2019·Chemical Reviews·Valentina CorradiD Peter Tieleman

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