Membrane homeostasis requires intact pst in extraintestinal pathogenic Escherichia coli.

Current Microbiology
Martin G Lamarche, Josée Harel

Abstract

In extraintestinal pathogenic Escherichia coli (ExPEC) strains, mutation in the PstSCAB inorganic phosphate transporter results in multiple sensitivity phenotypes and loss of virulence. Here, we show that a pst mutant is subject to an increased outer membrane permeability and that pst copy number influences fatty acids regulation. Such perturbations are likely to participate in the impaired response of pst mutants to their environment.

References

Apr 8, 1998·Molecular & General Genetics : MGG·B Spira, E Yagil
Apr 6, 2002·Current Opinion in Microbiology·John E Cronan
Feb 12, 2008·Nature Reviews. Microbiology·Yong-Mei Zhang, Charles O Rock
Nov 20, 2008·Current Microbiology·Meire Aguena, Beny Spira

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Citations

Aug 22, 2012·Antimicrobial Agents and Chemotherapy·Thomas KrahnKeith Poole
Jun 28, 2011·Veterinary Microbiology·Sébastien CrépinJosée Harel
Sep 13, 2016·PloS One·Gerardo A LeottaMarcelo Signorini
Dec 9, 2014·Virulence·Samuel Mohammed ChekababCharles M Dozois

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