PMID: 2118726Sep 1, 1990Paper

Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation

The American Journal of Physiology
J E Brayden

Abstract

Acetylcholine (ACh)-induced hyperpolarization of cerebral arteries requires a functional endothelium. The hyperpolarization is reversed by potassium-channel blockers. The goal of this study was to determine whether the hyperpolarization is causally related to endothelium-dependent dilation of isolated cerebral arteries. ACh hyperpolarized rabbit middle cerebral arteries by up to 19 mV. The hyperpolarizations were sustained and did not occur in arteries without endothelial cells or in the presence of potassium-channel inhibitors (3 x 10(-6) M glibenclamide or 5 x 10(-5) M BaCl2). ACh-induced dilator responses were inhibited but not abolished by glibenclamide or BaCl2. Methylene blue also inhibited the dilator responses, and a combination of glibenclamide or BaCl2 and methylene blue greatly diminished the dilation. Nitric oxide relaxed but did not hyperpolarize the vascular smooth muscle cells, and BaCl2 had no effect on the nitric oxide-induced relaxations. These data indicate that the overall cerebral arterial dilator response to ACh is determined by the combined effects of membrane hyperpolarization, which closes voltage-dependent calcium channels, and the actions of a second endothelial factor, probably endothelium-derived re...Continue Reading

Citations

Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·J E BrianF M Faraci
Jun 12, 1998·Japanese Journal of Pharmacology·N Toda, T Okamura
Jun 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Louise S HarringtonJane A Mitchell
Aug 1, 1994·Stroke; a Journal of Cerebral Circulation·F M FaraciD D Heistad
Jul 25, 2000·Journal of Applied Physiology·A D KayeB D Nossaman
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·M P BracamonteV M Miller
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N I Gokina, J A Bevan
Feb 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Nari KimEuiyong Kim
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·E M Golding, T E Kepler
Jun 18, 2005·American Journal of Respiratory Cell and Molecular Biology·Aziz HichamiNaim A Khan
Jul 29, 2010·Physiological Reviews·Thomas P FlaggColin G Nichols
Aug 29, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Julie Balch SamoraMatthew A Boegehold

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