PMID: 8613689Mar 1, 1996Paper

Membrane lipid peroxidation as a mechanism of sonodynamically induced erythrocyte lysis

International Journal of Radiation Biology
N YumitaR Nishigaki

Abstract

Sonodynamically induced lipid peroxidation with haematoporphyrin (Hp) was studied using rat erythrocytes. Both suspensions of erythrocyte ghosts and of intact erythrocytes were exposed to ultrasound in the same way in the presence and absence of Hp (80 microM). The lipid peroxidation in erythrocyte ghost membranes was estimated by measuring the amount of reactive substance produced from thiobarbituric acid added immediately after the exposure. Haematoporphyrin multiplied the ultrasonically induced lipid peroxidation by three to five times, while Hp alone showed no peroxidation. A 24-h interval between the exposure and the preparation for measurement did not increase the measured amount of peroxide. In the presence of Hp the estimated peroxidation rate and the rate of erythrocyte lysis correlated quite well for each acoustic condition and for each chemical condition such as the presence or absence of active oxygen scavengers in the suspension. The sonodynamically induced lipid peroxidation with Hp was doubled by deuterium oxide substitution for suspension medium and was significantly reduced by histidine, by sodium azide, and also by nitrogen substitution for saturation gas, whereas superoxide dismutase and mannitol showed no si...Continue Reading

References

Mar 1, 1990·Japanese Journal of Cancer Research : Gann·N YumitaS Umemura
Sep 1, 1990·Japanese Journal of Cancer Research : Gann·S UmemuraK Umemura
Mar 1, 1989·Japanese Journal of Cancer Research : Gann·N YumitaS Umemura
Aug 1, 1966·Analytical Biochemistry·Z A PlacerB C Johnson
Aug 1, 1994·International Journal of Radiation Biology·D KesselC Cain
May 1, 1993·Japanese Journal of Cancer Research : Gann·S UmemuraR Nishigaki

❮ Previous
Next ❯

Citations

Nov 12, 2013·Cancer Biotherapy & Radiopharmaceuticals·Qing LiQuanhong Liu
Nov 18, 2011·The Journal of the Acoustical Society of America·Douglas L Miller, Chunyan Dou
Mar 18, 2015·Molecular Medicine Reports·Xing LiuZheng-Gang Bi
Mar 10, 2010·Ultrasound in Medicine & Biology·Xiao Bing WangXiu Juan Li
Jan 18, 2005·Ultrasound in Medicine & Biology·Katarzyna MilowskaAndrzej Nowicki
Dec 14, 2005·Ultrasound in Medicine & Biology·Katarzyna Milowska, Teresa Gabryelak
Dec 1, 2002·Journal of Medical Ultrasonics·Loreto B FerilPeter Riesz
Oct 25, 2006·Australasian Physical & Engineering Sciences in Medicine·Z ShangY Zeng
Feb 24, 2006·Radiation Research·Manabu Kinoshita, Kullervo Hynynen
Dec 22, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Quanhong LiuYan Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Japanese Journal of Cancer Research : Gann
Shin-Ichiro UmemuraK Umemura
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L P SrivastavaP C Joshi
Japanese Journal of Cancer Research : Gann
Shin-Ichiro UmemuraR Nishigaki
© 2021 Meta ULC. All rights reserved