Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

The Journal of Physiology
Junji EgawaBrian P Head

Abstract

A better understanding of the cellular physiological role that plasma membrane lipids, fatty acids and sterols play in various cellular systems may yield more insight into how cellular and whole organ function is altered during the ageing process. Membrane lipid rafts (MLRs) within the plasma membrane of most cells serve as key organizers of intracellular signalling and tethering points of cytoskeletal components. MLRs are plasmalemmal microdomains enriched in sphingolipids, cholesterol and scaffolding proteins; they serve as a platform for signal transduction, cytoskeletal organization and vesicular trafficking. Within MLRs are the scaffolding and cholesterol binding proteins named caveolin (Cav). Cavs not only organize a multitude of receptors including neurotransmitter receptors (NMDA and AMPA receptors), signalling proteins that regulate the production of cAMP (G protein-coupled receptors, adenylyl cyclases, phosphodiesterases (PDEs)), and receptor tyrosine kinases involved in growth (Trk), but also interact with components that modulate actin and tubulin cytoskeletal dynamics (e.g. RhoGTPases and actin binding proteins). MLRs are essential for the regulation of the physiology of organs such as the brain, and age-related lo...Continue Reading

References

Aug 1, 1979·Neurochemical Research·K C LeskawaA Rosenberg
Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Feb 1, 1990·Journal of Neurochemistry·M SöderbergG Dallner
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L LiscumM S Brown
Jan 20, 1981·Biochemistry·J W Deutsch, R B Kelly
Nov 1, 1995·Journal of Neurochemistry·M RunquistG Dallner
Feb 1, 1995·Journal of Neurochemistry·H Jurevics, P Morell
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·D LütjohannI Björkhem
Jan 14, 1998·Neuron·G L MingM M Poo
Jun 5, 1998·The American Journal of Physiology·S D TurleyJ M Dietschy
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·E G LundD W Russell
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·L H ChamberlainG W Gould
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·Keith A Crutcher
May 1, 2002·The Journal of Cell Biology·Philipp NiethammerMelitta Schachner
Apr 11, 2003·The Journal of Biological Chemistry·Erik G LundDavid W Russell
May 22, 2003·Progress in Neurobiology·Ephron S Rosenzweig, Carol A Barnes
Mar 16, 2004·Neuroscience Letters·Florence RémyWolfgang Richter
Mar 20, 2004·Traffic·Christine SalaünLuke H Chamberlain
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gary A WaymanThomas R Soderling
May 20, 2004·The Journal of Biological Chemistry·John M SchmittThomas R Soderling
Aug 4, 2004·EMBO Reports·Anthony H Futerman, Yusuf A Hannun
Dec 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Ingemar Bjorkhem, Ulf Diczfalusy
Mar 3, 2005·Journal of Lipid Research·Maura HeverinIngemar Björkhem
Oct 13, 2005·Journal of Cell Science·Matthew A ChurchwardJens R Coorssen
Apr 29, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rea ValapertaSandro Sonnino
May 17, 2006·Neuroscience Letters·K M ThelenD Lütjohann

❮ Previous
Next ❯

Citations

Jun 3, 2016·Regenerative Biomaterials·Xiaochun XuXiangdong Kong
Aug 16, 2016·The Journal of Physiology·Ian D Forsythe
Dec 6, 2017·Frontiers in Molecular Neuroscience·Fabian ArenasJose C Fernandez-Checa
Jul 10, 2018·The International Journal of Neuropsychopharmacology·Jahad AlghamdiSandosh Padmanabhan
Jan 25, 2019·Muscle & Nerve·Maria A Gonzalez PorrasCarlos B Mantilla
Nov 21, 2019·Journal of Neurochemistry·Merja JoensuuFrédéric A Meunier
Feb 7, 2020·International Journal of Molecular Sciences·Simona DanieleClaudia Martini
Apr 30, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Junji EgawaBrian P Head
Sep 23, 2020·Scientific Reports·Brian HeadMaret G Traber
Apr 26, 2019·Investigative Ophthalmology & Visual Science·Muhammad Zain ChauhanSanjoy K Bhattacharya
Dec 6, 2019·Frontiers in Neuroscience·Daniel HenriquesLiliana S Mendonça
Aug 6, 2019·Frontiers in Cellular Neuroscience·Shanshan WangBrian P Head
Apr 20, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexey M Petrov, Irina A Pikuleva
May 13, 2020·Journal of Cell Science·Albert PolRobert G Parton
Jul 30, 2020·Scientific Reports·Miloslav KorinekLadislav Vyklicky
Mar 3, 2019·International Journal of Molecular Sciences·Igor I Krivoi, Alexey M Petrov
Oct 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Virginia BorroniFrancisco J Barrantes
Oct 8, 2020·International Journal of Molecular Sciences·Sofiia ReshetniakChristian Tetzlaff
Nov 21, 2020·International Journal of Molecular Sciences·Ryan P KreiserRyan Limbocker
Apr 27, 2020·Chemistry and Physics of Lipids·R Pérez-Isidoro, M Costas
Mar 23, 2021·Frontiers in Cellular Neuroscience·Rima RebiaiErnesto R Bongarzone
Apr 24, 2021·Developmental Cell·Ayse Sena MutluMeng C Wang
Apr 5, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Florina ZakanyZoltan Varga
May 14, 2021·Molecular Therapy. Methods & Clinical Development·Shanshan WangBrian P Head
Jul 27, 2021·Frontiers in Aging Neuroscience·Irina A Pikuleva, Nathalie Cartier
Sep 3, 2021·The Journal of Physical Chemistry. B·Ji Hun WiSo Yeon Kim
Sep 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hebah FataftaBirgit Strodel
Oct 9, 2021·Essays in Biochemistry·Tobias MollPamela J Shaw
Jun 12, 2021·Annual Review of Nutrition·William S BlanerMaret G Traber
Nov 11, 2021·Glycoconjugate Journal·Inka BrockhausenJennifer Brockhausen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.