Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking

Leukemia
Mariusz Z Ratajczak, Mateusz Adamiak

Abstract

Cell outer membranes contain glycosphingolipids and protein receptors, which are integrated into glycoprotein microdomains, known as lipid rafts, which float freely in the membrane bilayer. These structures have an important role in assembling signaling molecules (e.g., Rac-1, RhoH and Lyn) together with surface receptors, such as the CXCR4 receptor for α-chemokine stromal-derived factor-1, the α4β1-integrin receptor (VLA-4) for vascular cell adhesion molecule-1 and the c-kit receptor for stem cell factor, which together regulate several aspects of hematopoietic stem/progenitor cell (HSPC) biology. Here, we discuss the role of lipid raft integrity in the retention and quiescence of normal HSPCs in bone marrow niches as well as in regulating HSPC mobilization and homing. We will also discuss the pathological consequences of the defect in lipid raft integrity seen in paroxysmal nocturnal hemoglobinuria and the emerging evidence for the involvement of lipid rafts in hematological malignancies.

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Citations

Feb 20, 2016·Circulation Research·Mary G Sorci-Thomas, Michael J Thomas
Sep 25, 2017·Oncotarget·Gabriela SchneiderMariusz Z Ratajczak
Jun 27, 2015·Pediatric Transplantation·Mariusz Z Ratajczak
Feb 17, 2017·PloS One·Adam StefankoMichal Grzybek
May 21, 2016·Frontiers in Cell and Developmental Biology·Arnauld Sergé
Dec 14, 2018·Oncotarget·Mateusz AdamiakMariusz Z Ratajczak
Jun 26, 2020·International Journal of Molecular Sciences·Kamila PuchałowiczVioletta Dziedziejko
Oct 7, 2015·Clinical and Translational Medicine·Mariusz Z Ratajczak, Xiangdong Wang
Jun 21, 2018·Frontiers in Immunology·Mariusz Z RatajczakWieslaw Wiktor-Jedrzejczak
Jul 28, 2020·Frontiers in Immunology·Sibel KaraAnja Lux
Nov 5, 2016·Molecular Cancer·M Katie Conley-LaCombSreenivasa R Chinni
Sep 22, 2018·Frontiers in Oncology·Xingchen PangXiang Li
May 16, 2019·The Journal of Clinical Investigation·Darja KarpovaJohn F DiPersio
Nov 20, 2020·Blood Advances·Hakim Ouled-HaddouLoïc Garçon
Jan 26, 2021·Cellular Signalling·Chiara D'AprileSara Grassi
Jun 12, 2020·Stem Cells·Jane L LiesveldOmar S Aljitawi
Jan 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lijing YangJunping Wang
Apr 27, 2021·Current Opinion in Hematology·Mariusz Z Ratajczak, Magdalena Kucia

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