[Membrane lipids in schizophrenia and early phases of psychosis: Potential biomarkers and therapeutic targets?]

L'Encéphale
A FrajermanM-O Krebs

Abstract

The various roles of membrane lipids in human health has urged researchers to study their impact in neuropsychiatric diseases, especially in schizophrenia spectrum disorders and more recently in early stages of psychosis. The progress in mass spectrometry technologies now allows a more comprehensive analysis of phospholipids (PL) and their fatty acid (FA) molecular species. FA are defined by a carbon chain of variable length and are said to be unsaturated when their chain has one or more carbon-carbon double bonds. The PL are composed of a hydrophilic polar head with a phosphoric acid group and an hydrophobic part with FAs; they encompass glycerophospholipids and sphingolipids. The plasma membrane is a complex and dynamic structure consisting of a lipid bilayer composed of an outer layer and an inner layer of specific lipid composition. The permanent remodeling of membrane lipids involves phospholipases especially the phospholipase A2. Seventy percent of the brain consists of lipids from different classes and molecular species. Most of the brain lipids are composed of polyunsaturated fatty acid (PUFA)-enriched diacyl classes where omega-3 and omega-6 molecular species predominate. The balance between omega-3 and omega-6 is impo...Continue Reading

References

Apr 30, 1977·Lancet·D F Horrobin
Feb 20, 1992·Nature·B MillerD Attwell
Oct 1, 1994·Schizophrenia Research·D F HorrobinK Vaddadi
Jul 25, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S WatanabeT Hamazaki
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gwendolyn Barceló-CoblijnTibor Farkas
Mar 26, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Lloyd A Horrocks, Akhlaq A Farooqui
Sep 30, 2004·Journal of Cognitive Neuroscience·Zoltan NagyTorkel Klingberg
Feb 22, 2005·Journal of Lipid Research·Eoin FahyEdward A Dennis
Mar 29, 2005·Nature Neuroscience·Gesine SaherKlaus-Armin Nave
Sep 12, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sylvie Chalon
Sep 16, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Irina Fedorova, Norman Salem
Feb 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefan SmesnyHeinrich Sauer
Dec 29, 2007·The Journal of Clinical Psychiatry·Gregor E BergerPatrick D McGorry
Jan 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregor E BergerPatrick D McGorry
May 19, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Manabu MakinodanToshifumi Kishimoto
Dec 15, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Stefan SmesnyGregor E Berger
Feb 1, 2011·Nature Neuroscience·Mathieu LafourcadeOlivier J Manzoni
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Wenting ZhangYanqin Gao
Jul 10, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sarah K OrrRichard P Bazinet
Aug 29, 2012·Schizophrenia Bulletin·Bart D PetersLieuwe de Haan
Feb 23, 2013·Journal of Psychiatric Research·Ameer Y TahaJagadeesh S Rao
Sep 18, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean-Christophe DelpechSophie Layé
Feb 24, 2015·Biochimica Et Biophysica Acta·Glyn Dawson
May 26, 2015·Schizophrenia Research·Paul L Wood, Nicole R Holderman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved