Membrane-lytic actions of sulphonated methyl ester surfactants and implications to bactericidal effect and cytotoxicity

Journal of Colloid and Interface Science
Fang PanJian R Lu

Abstract

Surfactants are multifunctional molecules widely used in personal care and healthcare formulations to cleanse, help disperse active ingredients (e.g., forming emulsions) and stabilise products. With increasing demands on improving biosafety, there is now mounting pressure to understand how different surfactants elicit toxicities at molecular and cellular levels. This work reports the membrane-lytic behaviour of a group of sulphonated methyl ester (SME) surfactants together with representative conventional surfactants. All surfactants displayed the clear rise of lysis of the model lipid bilayer membranes around their CMCs, but the two ionic surfactants SDS and C12TAB even caused measurable lysis below their CMCs, with membrane-lytic actions increasing with monomer concentration. Furthermore, whilst ionic and nonionic surfactants could achieve full membrane lysis once above their CMCs, this ability was weak from the SME surfactants and decreased with increasing the acyl chain length. In contrast to the conventional anionic surfactants such as SDS and SLES, the protein solubilizing capability of the SME surfactants was also low. On the other hand, MTT assays against 3T3 fibroblast cells and human chondrocyte cells revealed high to...Continue Reading

Citations

Nov 23, 2018·Acta Biomaterialia·Cristobal Garcia Garcia, Kristi L Kiick
Dec 2, 2020·ACS Applied Materials & Interfaces·Haoning GongJian Ren Lu
Sep 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Fang PanXiubo Zhao
Aug 27, 2019·ACS Applied Materials & Interfaces·Haoning GongJian Ren Lu

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