Membrane manipulations by the ESCRT machinery

F1000Research
Greg Odorizzi

Abstract

The endosomal sorting complexes required for transport (ESCRTs) collectively comprise a machinery that was first known for its function in the degradation of transmembrane proteins in the endocytic pathway of eukaryotic cells. Since their discovery, however, ESCRTs have been recognized as playing important roles at the plasma membrane, which appears to be the original site of function for the ESCRT machinery. This article reviews some of the major research findings that have shaped our current understanding of how the ESCRT machinery controls membrane dynamics and considers new roles for the ESCRT machinery that might be driven by these mechanisms.

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Apr 28, 2016·FEBS Letters·Janina HanneHans-Georg Kräusslich
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Jun 1, 2021·Autophagy·Jason P ChuaSami J Barmada
Mar 15, 2016·Brain Research·Christopher S Krasniak, S Tariq Ahmad

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Methods Mentioned

BETA
electron microscopy
super-resolution microscopy
light microscopy
electron tomography

Software Mentioned

ESCRT

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