PMID: 8590916Mar 1, 1995Paper

Membrane-mediated effects of catecholamines on the DNA of human leukocytes: the role of reactive oxygen species

Biological Signals
M E Crespo, M P Bicho

Abstract

The effects of epinephrine and two other beta 2-adrenergic agonists, ritodrine and isoxsuprine, on the induction of damage to the DNA (production of strand breaks) in human leukocytes were studied by fluorescence analyses of unwinding DNA. Epinephrine stimulated the development of DNA strand breaks. Ritodrine and isoxsuprine inhibited this effect of epinephrine on the human leukocytes by competition for binding to receptors, but they were not oxidized to the same extent as epinephrine. Metoprolol, which acts predominantly as a beta 1-antagonist, demonstrated a beta 2-antagonism, as compared with epinephrine. Since the o-oxidation of epinephrine involves the production of damaging oxygen species such as O2-. and H2O2, we studied the effects on DNA of extracellular H2O2 in the presence and absence of epinephrine. Extracellular H2O2 induced significant damage to the DNA, but it had a smaller effect when applied with epinephrine. The results obtained with 3-amino-1,2,4-triazole, an inhibitor of endogenous catalase, were not significantly different from control results, under our experimental conditions. Nevertheless, this compound had a mitigating effect when applied with epinephrine. We also investigated the action of nicotinamide...Continue Reading

Citations

Jul 19, 2012·Clinical Epidemiology·Paul J Fitzgerald
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ayako HakuchoTatsuya Fujimiya
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·S Marra, L Hoffman-Goetz
Dec 26, 2018·Oxidative Medicine and Cellular Longevity·Milena RadakovićZoran Stanimirović
Jun 30, 2019·International Journal of Molecular Sciences·Maria Moreno-VillanuevaMarkus Gruber

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