PMID: 9651487Jul 4, 1998Paper

Membrane permeabilisation and antimycoplasmic activity of the 18-residue peptaibols, trichorzins PA

Biochimica Et Biophysica Acta
L BevenH Wróblewski

Abstract

The membrane permeabilisation properties of six linear natural 18-residue peptaibols, termed trichorzins PA, have been assessed on liposomes and on mollicutes (trivial name, mycoplasmas), a class of parasitic bacteria characterized by a small genome, the lack of a cell wall, a minute cell size, and the incorporation in their plasma membrane of exogenously supplied cholesterol. The trichorzins PA used in this study (PA II, PA IV-VI, PA VIII, and PA IX) differ between them by amino acid or amino alcohol substitutions at positions 4, 7, and 18, and form slightly amphipathic alpha-helices. They proved bactericidal for mollicutes belonging to the genera Acholeplasma, Mycoplasma, and Spiroplasma, with minimal inhibitory concentrations (3.12</=MICs</=50 microM) generally 2 to 4 fold higher than those of alamethicin F50, a related 20-residue peptide (1.56</=MICs</=12.5 microM). Spiroplasma cells were apparently not protected by the presence of spiralin on their surface. The activities of the six trichorzins PA were not influenced by their sequence variations and no synergistic effect was observed. Consistent with the marginal effect of cholesterol on the incorporation of the trichorzins PA into liposome bilayers, the antibiotic activit...Continue Reading

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Citations

Dec 22, 1999·Current Opinion in Chemical Biology·P Scrimin, P Tecilla
Nov 14, 2014·SpringerPlus·João Pc BritoCirano J Ulhoa
Jun 26, 2007·Chemistry & Biodiversity·Balázs LeitgebLászló Kredics
Jun 26, 2007·Chemistry & Biodiversity·Sonia RippaLaure Béven
Jan 18, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Wei ZhangYingxia Li
Dec 9, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·Cristina PeggionClaudio Toniolo
Sep 28, 2007·Natural Product Reports·Juliana F de S Daniel, Edson Rodrigues Filho
Jul 12, 2005·Acta Microbiologica Et Immunologica Hungarica·A SzekeresCs Vágvölgyi
Aug 10, 2010·Journal of Bacteriology·Ségolène CabochePhilippe Jacques
May 16, 2020·Journal of Fungi·Xiaoyan NiuQiongbo Hu
Feb 19, 2021·Journal of Natural Products·Anne-Isaline van BohemenYves François Pouchus

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