PMID: 8948478Nov 13, 1996Paper

Membrane permeability and stability in buffer and in human serum of fluorinated di-O-alkylglycerophosphocholine-based liposomes

Biochimica Et Biophysica Acta
V RavilyP Vierling

Abstract

The stability (with respect to encapsulated carboxyfluorescein release) of liposomes made from various fluorocarbon 1,2-or 1,3-di-O-alkylglycerophosphocholines (ether-connected) and their membrane permeability have been investigated in buffer and in human serum. Membranes and liposomes, whether formulated with fluorocarbon/fluorocarbon or mixed fluorocarbon/hydrocarbon, 1,2- or 1,3-di-O-alkylglycerophospholipids, display lower permeability coefficients and are able to retain more efficiently encapsulated CF, even when incubated in human serum, than any of their conventional counterparts. These fluorinated liposomes are as stable as the first generation of liposomes formulated with their fluorocarbon ester-connected 1,2-di-O-acylglycerophosphocholine analogs. These results further confirm that a fluorinated intramembranar layer reduces the permeability of membranes (more significantly when they are in a fluid state), protects them from the destabilizing effects of serum components and increases even the stability of the fluorinated liposomes whose membranes are in the gel state when incubated in human serum. The impact of the modular structure of the fluorinated phospholipids (number of fluorocarbon chains, ether vs. ester bond,...Continue Reading

Citations

Feb 11, 2000·Chemistry and Physics of Lipids·M ForadadaJ Estelrich
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·L ClaryP Vierling
Dec 24, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·C GadrasP Vierling
Dec 22, 1999·International Journal of Pharmaceutics·G B PatelG D Sprott
Feb 15, 2011·International Journal of Pharmaceutics·Bowen TianKostas Kostarelos
Jul 21, 2015·International Journal of Pharmaceutics·Sara Munk JensenMartin Brandl
May 3, 2016·The Journal of Physical Chemistry. B·Yue HuangFiorenzo Vetrone
Jun 21, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Jiehua LiXia Jiang
Apr 20, 2005·The Journal of Chemical Physics·Matthias F SchneiderMotomu Tanaka
Jun 19, 2018·Organic & Biomolecular Chemistry·Marie-Claude GagnonJean-François Paquin

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