PMID: 6536667Jan 1, 1984Paper

Membrane plasma exchange: principles and application techniques

Journal of Clinical Apheresis
W SamtlebenH J Gurland

Abstract

Membrane plasmapheresis was introduced in 1978 as a new method for performing therapeutic plasma exchange. Its principal advantages over traditional techniques include speed, ease of performance, and ready adaptability to clinical centers already performing routine extracorporeal therapy. The appearance of a membrane plasmapheresis circuit (vascular access, anticoagulation, connectology) is similar to that of hemodialysis and especially hemofiltration; the operating protocols (treatment time, filtration rates, pressures, pharmacokinetics) are quite different. Particular attention must be paid to avoiding operating conditions that lead to hemolysis. In clinical use membrane plasma separation is as effective as centrifugal plasma exchange in removing plasma proteins. The sieving coefficients for proteins with a molecular weight (MW) ranging from 67,000 (albumin) to 2,400,000 (beta-lipoprotein) daltons are unity. An exchange of one patient plasma volume has been shown to cause a 55% reduction of the serum levels of intravascular proteins. There are no significant differences between membrane and centrifugal plasmapheresis in substitution fluid requirements (human albumin or fresh frozen plasma), indications for treatment and compl...Continue Reading

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Citations

Aug 1, 1997·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·H E Kambic, Y Nosé
Jan 1, 1990·Intensive Care Medicine·P M Reimann, P D Mason
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S SchmaldienstP Knöbl
Jan 1, 1988·Environmental Pollution·J R Shann, D C Adriano
Jul 23, 2013·Food Chemistry·Shuchen HsiehFeng-Huei Lin
Nov 29, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Siami, F S Siami
Mar 18, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Siami, F S Siami
Feb 2, 2017·Journal of Clinical Apheresis·Aurélie LemaireEmmanuel Canet
Nov 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Mark E Williams, Rasheed A Balogun
Mar 20, 1993·Annals of the New York Academy of Sciences·P StrangB Tribukait

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