Membrane platforms for biological nanopore sensing and sequencing

Current Opinion in Biotechnology
Jacob Schmidt

Abstract

In the past two decades, biological nanopores have been developed and explored for use in sensing applications as a result of their exquisite sensitivity and easily engineered, reproducible, and economically manufactured structures. Nanopore sensing has been shown to differentiate between highly similar analytes, measure polymer size, detect the presence of specific genes, and rapidly sequence nucleic acids translocating through the pore. Devices featuring protein nanopores have been limited in part by the membrane support containing the nanopore, the shortcomings of which have been addressed in recent work developing new materials, approaches, and apparatus resulting in membrane platforms featuring automatability and increased robustness, lifetime, and measurement throughput.

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Citations

Dec 14, 2016·Analytical Chemistry·Toshihisa Osaki, Shoji Takeuchi
Jul 7, 2017·Nature Nanotechnology·Stefan Howorka
Apr 20, 2018·Journal of the Royal Society, Interface·Nobuo MisawaShoji Takeuchi
Feb 7, 2017·Journal of Electroanalytical Chemistry·Samuel S Hinman, Quan Cheng
Aug 29, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Daniel L BurdenLisa M Keranen Burden

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