PMID: 5912216Jun 1, 1966

Membrane potential and conductance during transport of sodium, potassium and rubidium in frog muscle

The Journal of Physiology
R H Adrian, C L Slayman


1. Muscles with high intracellular sodium concentrations can extrude sodium into solutions which contain 10 m-equiv/l. of either potassium or rubidium. Potassium or rubidium replaces the extruded intracellular sodium. These cation movements take place equally well when the external anion is chloride or sulphate, though muscles deteriorate if left for long periods in sulphate solutions.2. Measurements of intracellular potentials during extrusion of sodium into solutions containing potassium show:(a) an internal potential more negative than the potassium equilibrium potential (E(K)); at 20 degrees C the difference is nearly 20 mV.(b) that a difference between the membrane potential and E(K) is dependent on temperature and is abolished by 10(-5)M ouabain.(c) an internal potential which becomes more negative in the presence of 0.1% cocaine, a concentration of cocaine which substantially increases the membrane resistance to potassium movement. In the absence of potassium or rubidium no such hyperpolarization occurs.3. When muscles extrude into solutions which contain rubidium they have internal potentials which are 10-20 mV more negative than when extruding sodium into corresponding solutions containing potassium.4. Measurements of ...Continue Reading


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