Membrane potential and ion concentration stability conditions for a cell with a restricted extracellular space

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
D AttwellD Eisner

Abstract

For an isolated membrane, the resting (zero current) potential is stable is the slope conductance is positive, and is unstable if the slope conductance is negative. Recent work suggests that the properties of many preparations are influenced by the presence of an extracellular space that is not in good diffusive contact with the bulk extracellular fluid. Ionic current flow across the membrane changes the ion concentrations in this space. These concentration changes affect the stability of the membrane potential. Even if the slope conductance is negative, the presence of the extracellular space can confer stability on the resting potential. Conversely, even if the slope conductance is positive, the extracellular space can produce instability of the resting potential. Evaluation of the relevant parameters for cardiac Purkinje fibres, from published experimental data, suggests that concentration changes in the extracellular space may play a significant role in determining when an action potential is initiated.

References

Jan 1, 1983·The Journal of Membrane Biology·J B ChapmanJ M Kootsey
Apr 13, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·M PásekG Christé
Mar 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Katharine DibbDavid Eisner
Sep 18, 2007·Progress in Biophysics and Molecular Biology·M PásekC H Orchard
Aug 1, 1979·Quarterly Reviews of Biophysics·D AttwellI Cohen

Citations

Nov 1, 1977·Electroencephalography and Clinical Neurophysiology·P F Dunn, W A Wilson
Jul 1, 1976·The Journal of Physiology·S J Noble
Jan 1, 1973·The Journal of Membrane Biology·D W Maughan
Feb 28, 1956·The Journal of Physiology·B FRANKENHAEUSER, A L HODGKIN
Dec 1, 1969·The Journal of Membrane Biology·R W Tsien, D Noble

Related Concepts

Structure of Purkinje Fibers
Membrane
Resting Potentials
Extracellular Space
Extracellular Fluid
Dall Sheep
Anatomical Space Structure
Evaluation
Metazoa
Osmolality

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