PMID: 5921533May 1, 1966

Membrane potential and ion content in the smooth muscle of the guinea-pig's taenia coli at different external potassium concentrations

The Journal of Physiology
R Casteels, H Kuriyama

Abstract

1. The relation between the membrane potential and the intracellular ion concentration of the taenia coli was studied in solutions with different external potassium concentrations.2. Isotonic solution in which the sum of NaCl+KCl was constant did not produce swelling of the smooth muscle of taenia coli, even at high [K](o), and did not change the intracellular chloride concentration.3. Addition of an equivalent amount (118 mM) of NaCl or KCl to Krebs solution produced the same loss of water.4. Solutions in which the product [K][Cl] was kept constant decreased the internal chloride concentration so that the chloride equilibrium potential became temporarily positive and returned only after 2 hr to a negative value.5. From these results and the finding that even in normal Krebs solution E(Cl) was about 35 mV more positive than the membrane potential, it is concluded that the chloride ions are not passively distributed. The potassium equilibrium potential is the main factor in the generation of the membrane potential. The large discrepancy between the two can be explained by the non-passive chloride distribution and by the sodium permeability of the membrane. The maintenance of the normal cell volume in solutions with constant sum ...Continue Reading

Citations

Feb 1, 1970·Acta Physiologica Scandinavica·H HaljamäeH Röckert
Mar 1, 1967·The American Journal of Digestive Diseases·R Casteels
Jun 1, 1985·Experimental Parasitology·S D Holmes, I Fairweather
Mar 2, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C B KölbelE A Mayer
Apr 20, 1968·Nature·A F Brading, T Tomita
Jul 1, 1980·Pflügers Archiv : European journal of physiology·J H Widdicombe, A F Brading
Apr 9, 1975·Pflügers Archiv : European journal of physiology·J RiemerG Ulbrecht
Jan 31, 1979·Pflügers Archiv : European journal of physiology·E M Lieberman
Nov 5, 1976·Pflügers Archiv : European journal of physiology·B HohorstK Greven
Sep 1, 1979·Pflügers Archiv : European journal of physiology·E Zelcer
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E Bülbring, T Tomita
May 1, 1989·British Journal of Pharmacology·C D FosterA F Brading

Related Concepts

Cell Membrane Permeability
Chloride Ion Level
Cavia porcellus
Large Intestine
Isotonic Solutions
Smooth Muscle
Potassium
Sodium

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