PMID: 5921533May 1, 1966

Membrane potential and ion content in the smooth muscle of the guinea-pig's taenia coli at different external potassium concentrations

The Journal of Physiology
R Casteels, H Kuriyama


1. The relation between the membrane potential and the intracellular ion concentration of the taenia coli was studied in solutions with different external potassium concentrations.2. Isotonic solution in which the sum of NaCl+KCl was constant did not produce swelling of the smooth muscle of taenia coli, even at high [K](o), and did not change the intracellular chloride concentration.3. Addition of an equivalent amount (118 mM) of NaCl or KCl to Krebs solution produced the same loss of water.4. Solutions in which the product [K][Cl] was kept constant decreased the internal chloride concentration so that the chloride equilibrium potential became temporarily positive and returned only after 2 hr to a negative value.5. From these results and the finding that even in normal Krebs solution E(Cl) was about 35 mV more positive than the membrane potential, it is concluded that the chloride ions are not passively distributed. The potassium equilibrium potential is the main factor in the generation of the membrane potential. The large discrepancy between the two can be explained by the non-passive chloride distribution and by the sodium permeability of the membrane. The maintenance of the normal cell volume in solutions with constant sum ...Continue Reading


Feb 1, 1970·Acta Physiologica Scandinavica·H HaljamäeH Röckert
Mar 1, 1967·The American Journal of Digestive Diseases·R Casteels
Jun 1, 1985·Experimental Parasitology·S D Holmes, I Fairweather
Mar 2, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C B KölbelE A Mayer
Apr 20, 1968·Nature·A F Brading, T Tomita
Jul 1, 1980·Pflügers Archiv : European journal of physiology·J H Widdicombe, A F Brading
Apr 9, 1975·Pflügers Archiv : European journal of physiology·J RiemerG Ulbrecht
Jan 31, 1979·Pflügers Archiv : European journal of physiology·E M Lieberman
Nov 5, 1976·Pflügers Archiv : European journal of physiology·B HohorstK Greven
Sep 1, 1979·Pflügers Archiv : European journal of physiology·E Zelcer
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E Bülbring, T Tomita
May 1, 1989·British Journal of Pharmacology·C D FosterA F Brading

Related Concepts

Cell Membrane Permeability
Chloride Ion Level
Cavia porcellus
Large Intestine
Isotonic Solutions
Smooth Muscle

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.