Membrane potential measurements during rat liver regeneration

Journal of Cellular Physiology
R Wondergem, D R Harder

Abstract

Membrane potential was measured in perfused rat liver and was shown to increase from -33 +/- 1.0 mV in livers from normal rats to -50 +/- 1.1 mV in livers from rats 12 hr after partial hepatectomy. The hyperpolarization of the membrane in regenerating liver was no longer evident after perfusion with 1 mM ouabain for 5 min. Ouabain had a small (4 mV) depolarizing effect on membrane potential in normal liver. The potential measured in normal and regenerating liver decreased as a function of the external potassium concentration above 5 mM; however, the potential was more electronegative in regenerating liver compared to normal liver at all values of external potassium concentration, and the differences in potential between the two kinds of cells did not decrease at higher concentrations of external potassium. Thus, a plot of membrane potential vs external potassium concentration resulted in approximately parallel curves for the two different cell types. We conclude that hyperpolarization of the liver cell membrane is an early event during rat liver regeneration and results from an electrogenic Na-K pump.

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Citations

Nov 1, 1981·The Journal of Cell Biology·D J MeyerJ P Revel
Apr 21, 2001·The Journal of Physiology·R WondergemK E Ferslew
Apr 1, 1989·Bioscience Reports·A TrentalanceS K Erickson
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Jan 10, 2019·IUBMB Life·Richard L VeechWilliam Curtis
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Sep 1, 1993·Journal of Cellular Physiology·M BocchettaA D Cooper
Jul 1, 1980·Journal of Cellular Physiology·R Wondergem, D R Harder
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Richard L VeechWilliam Curtis
Jun 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·D SunG Y Minuk
Mar 29, 2005·Molecular and Cellular Biochemistry·F J BurczynskiS Robert
Mar 9, 2013·Journal of Pediatric Gastroenterology and Nutrition·Vidyut BhatiaMohammad Irshad
Dec 16, 1986·Biochimica Et Biophysica Acta·E Petzinger, H Bigalke

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