PMID: 6402013Mar 9, 1983Paper

Membrane potential plays a dual role for chloride transport across toad skin

Biochimica Et Biophysica Acta
E H Larsen, B E Rasmussen

Abstract

The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.

References

Jun 2, 1958·Acta Physiologica Scandinavica·V KOEFOED-JOHNSEN, H H USSING

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Citations

Oct 1, 1988·Pflügers Archiv : European journal of physiology·F Lacaz-Vieira, J Procopio
Aug 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J Procopio
Jul 1, 1992·The American Journal of Physiology·W Nagel, W Van Driessche

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